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APEX1 [nucleoplasm]
Stable Identifier
R-MMU-50119
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
P28352
Locations in the PathwayBrowser
Expand all
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Resolution of Abasic Sites (AP sites) (Mus musculus)
APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of DNA glycosylase by APEX1 (Mus musculus)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Mus musculus)
Oxidative damage to the AP site (Mus musculus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
PCNA-Dependent Long Patch Base Excision Repair (Mus musculus)
LIG1 binds APEX1 and PCNA at SSB (Mus musculus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
LIG1 bound to APEX1 and PCNA ligates SSB (Mus musculus)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB-Dependent Long Patch Base Excision Repair (Mus musculus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Recruitment of POLB to oxidatively damaged AP site (Mus musculus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Resolution of AP sites via the single-nucleotide replacement pathway (Mus musculus)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Mus musculus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
Recruitment of POLB to the AP site (Mus musculus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P28352
Reference Genes
BioGPS Gene:11792
ENSEMBL:ENSMUSG00000035960
Monarch:11792
NCBI Gene:11792
UCSC:P28352
Reference Transcript
RefSeq:NM_009687.2
Other Identifiers
10414522
11792
1416135_at
1437715_x_at
1456079_x_at
17299542
4808485
4839965
4881871
5199357
5221116
5230481
5277606
5337733
5615943
93559_at
A_51_P473576
A_66_P135169
GE35075
GO:0000723
GO:0003677
GO:0003684
GO:0003691
GO:0003713
GO:0003723
GO:0003824
GO:0003906
GO:0004518
GO:0004519
GO:0004521
GO:0004527
GO:0005634
GO:0005654
GO:0005667
GO:0005730
GO:0005737
GO:0005739
GO:0005783
GO:0005813
GO:0005815
GO:0006281
GO:0006284
GO:0006308
GO:0006310
GO:0006325
GO:0006355
GO:0008081
GO:0008296
GO:0008309
GO:0008311
GO:0008408
GO:0014912
GO:0016491
GO:0016607
GO:0016787
GO:0016890
GO:0031490
GO:0032200
GO:0042981
GO:0043226
GO:0043488
GO:0044029
GO:0044877
GO:0045454
GO:0045944
GO:0046872
GO:0048471
GO:0051059
GO:0052720
GO:0060090
GO:0070301
GO:0090580
GO:0097698
GO:0140097
GO:0140098
GO:0140110
GO:0140431
GO:1900087
ILMN_2776952
ILMN_2918114
mMC016077
u12273_s_at
Participates
as an output of
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)
as a component of
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Mus musculus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:AP-dsDNA [nucleoplasm] (Mus musculus)
as an input of
Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)
Inferred From
APEX1 [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSMUST00000049411
,
ENSMUSP00000042602
PRO
P28352
MGI
88042
PDB
7CD6
,
7CD5
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