Per1,Per2 [cytosol]

Stable Identifier
R-MMU-508669
Type
Set [DefinedSet]
Species
Mus musculus
Compartment
General

In mouse either Per2 or Per1 is sufficient to maintain circadian rhythm. Per3 is not sufficient. Per2 appears to function mainly in the suprachiasmatic nucleus. Per3 appears to function mainly in peripheral tissues.

Literature References
PubMed ID Title Journal Year
14701732 Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock

Lee, C, Weaver, DR, Reppert, SM

Mol Cell Biol 2004
20072700 Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis

Pendergast, JS, Friday, RC, Yamazaki, S

PLoS One 2010
11389837 Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock

Zheng, B, Albrecht, U, Kaasik, K, Sage, M, Lu, W, Vaishnav, S, Li, Q, Sun, ZS, Eichele, G, Bradley, A, Lee, CC

Cell 2001
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