Expression of Bmal1 (Arntl)

Stable Identifier
R-MMU-508681
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Bmal1 (Arntl)

The RORalpha nuclear receptor (Rora) together with the coactivators p300 (Ep300) and PGC-1alpha (Ppargc1a) bind the promoter of the Bmal1 (Arntl) gene and activate transcription of Bmal1.

Literature References
PubMed ID Title Journal Year
12150932 The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

Preitner, N, Damiola, F, Lopez-Molina, L, Zakany, J, Duboule, D, Albrecht, U, Schibler, U

Cell 2002
12152080 A transcription factor response element for gene expression during circadian night

Ueda, HR, Chen, W, Adachi, A, Wakamatsu, H, Hayashi, S, Takasugi, T, Nagano, M, Nakahama, K, Suzuki, Y, Sugano, S, Iino, M, Shigeyoshi, Y, Hashimoto, S

Nature 2002
15312651 A functional genomics strategy reveals Rora as a component of the mammalian circadian clock

Sato, TK, Panda, S, Miraglia, LJ, Reyes, TM, Rudic, RD, McNamara, P, Naik, KA, FitzGerald, GA, Kay, SA, Hogenesch, JB

Neuron 2004
15821743 The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1

Akashi, M, Takumi, T

Nat Struct Mol Biol 2005
16267379 Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors

Guillaumond, F, Dardente, H, Giguère, V, Cermakian, N

J Biol Rhythms 2005
10652231 Rhythmic expression of BMAL1 mRNA is altered in Clock mutant mice: differential regulation in the suprachiasmatic nucleus and peripheral tissues

Oishi, K, Fukui, H, Ishida, N

Biochem Biophys Res Commun 2000
15135064 Bidirectional role of orphan nuclear receptor RORalpha in clock gene transcriptions demonstrated by a novel reporter assay system

Nakajima, Y, Ikeda, M, Kimura, T, Honma, S, Ohmiya, Y, Honma, K

FEBS Lett 2004
15761026 The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene

Yin, L, Lazar, MA

Mol Endocrinol 2005
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Nr1d1:heme:Corepressors:Arntl gene [nucleoplasm] (Mus musculus)
Summation

Rev-erbA-alpha (Rev-Erba, Nr1d1) recruits corepressors of the NCOR complex to the promoter of the Bmal1 gene.

Positively by
Regulator
Rora:Coactivator:Arntl gene [nucleoplasm] (Mus musculus)
Summation

The RORalpha nuclear receptor (Rora) together with the coactivators p300 (Ep300) and PGC-1alpha (Ppargc1a) bind the promoter of the Bmal1 (Arntl) gene and activate transcription of Bmal1.

Orthologous Events
ARNTL gene produces ARNTL (Homo sapiens)
Authored
May, B  (2010-02-12)
Reviewed
Albrecht, U  (2010-06-23)
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Created
May, B  (2010-02-16)
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