Cry proteins are ubiquitinylated

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Cry proteins are ubiquitinylated

Polyubiquitination of Cry proteins is directed by the Fbxl3 component of SCF E3 ubiquitin ligase located in the nucleoplasm. The polyubiquitinated Cry proteins are recognized and degraded by the 26S proteasome. Degradation of Cry proteins occurs during the night and is necessary to allow new transcription of Bmal1:Clock/Npas2 (Arntl:Clock/Npas2) targets in the morning during the circadian cycle.

Literature References
PubMed ID Title Journal Year
17463252 The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period

Lalanne, Z, Shaw, L, Hastings, MH, Tucci, V, Pagano, M, Barnard, AR, Nolan, PM, Brooker, D, O'neill, J, Chesham, JE, Kendall, R, Busino, L, Quwailid, MM, Maywood, ES, Godinho, SI, Romero, MR

Science 2007
17463251 SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

Maiolica, A, Busino, L, Draetta, GF, Bassermann, F, Godinho, SI, Lee, C, Pagano, M, Nolan, PM

Science 2007
17462724 Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression

Siepka, SM, Song, W, Hu, Y, Yoo, SH, Lee, C, Park, J, Takahashi, JS, Kumar, V

Cell 2007
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