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Cflar [cytosol]
Stable Identifier
R-MMU-51925
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CFLAR(1-376), O35732
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
Cflar [cytosol] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
CASP8 activity is inhibited (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
Cflar [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
Cflar [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Mus musculus)
Cflar [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
Cflar [cytosol] (Mus musculus)
TRAIL signaling (Mus musculus)
TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)
Cflar [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O35732
Gene Names
Cflar
Reference Genes
BioGPS Gene:12633 Cflar
ENSEMBL:ENSMUSG00000026031
ENSEMBL:ENSMUSG00000026031.16 Cflar
KEGG Gene (Mus musculus):12633 Cflar
Monarch:12633 Cflar
NCBI Gene:12633 Cflar
Reference Transcript
RefSeq:XM_011238423.2 Cflar
RefSeq:XM_017313559.1 Cflar
RefSeq:NM_001289704.2 Cflar
RefSeq:NM_207653.5 Cflar
RefSeq:XM_006495635.3 Cflar
RefSeq:XM_011238420.2 Cflar
RefSeq:XM_011238421.2 Cflar
RefSeq:XM_011238422.1 Cflar
Other Identifiers
103217_at
10346551
10346562
10497931
115031_at
115415_at
12633
1424996_at
1425686_at
1425687_at
1449317_at
17213192
4328239
4390102
4402971
4486302
4533420
4564374
4578068
4618742
4682189
4843537
4853719
4894262
4917024
4931141
4931167
4968242
5046127
5061927
5063153
5100036
5257786
5297570
5440765
5461982
5470775
5506626
5537927
A_51_P135491
A_51_P326091
A_52_P226929
A_55_P1983459
A_55_P1983468
A_55_P2507290
GE113455
GE35152
GO:0002020
GO:0002376
GO:0003012
GO:0003824
GO:0004197
GO:0005123
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006508
GO:0006915
GO:0007010
GO:0007519
GO:0008047
GO:0008234
GO:0009617
GO:0010667
GO:0010976
GO:0012501
GO:0014732
GO:0014842
GO:0014866
GO:0016504
GO:0016787
GO:0023052
GO:0030154
GO:0030182
GO:0030198
GO:0030216
GO:0030218
GO:0031264
GO:0031265
GO:0033574
GO:0042060
GO:0042981
GO:0043065
GO:0043066
GO:0043403
GO:0044877
GO:0048856
GO:0051092
GO:0060544
GO:0060546
GO:0070266
GO:0070374
GO:0071732
GO:0072126
GO:0097153
GO:0097342
GO:0098772
GO:0140096
GO:1901740
GO:1902042
GO:1903055
GO:1903427
GO:1903845
GO:1903944
GO:1904036
GO:2000347
GO:2001237
ILMN_2743945
ILMN_2748129
mMC020116
mMR029595
u97076_s_at
Participates
as a component of
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
as an input of
FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
This entity regulates
Negatively
TRAIL:TRAIL receptor trimers bind FADD
(Mus musculus)
Other forms of this molecule
Cflar [cytosol]
Cflar [cytosol]
Cflar [cytosol]
Cflar [cytosol]
Inferred From
CFLAR(1-376) [cytosol]
(Homo sapiens)
CFLAR(1-376) [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_017169048.1
,
NP_997536.1
,
XP_011236722.1
,
NP_001276633.1
,
XP_011236724.1
,
XP_011236723.1
,
XP_006495698.1
,
XP_011236725.1
Ensembl
ENSMUST00000114309
,
ENSMUSP00000065107
,
ENSMUSP00000109948
,
ENSMUST00000069333
,
ENSMUSP00000109952
,
ENSMUSG00000026031
,
ENSMUST00000114313
PRO
O35732
MGI
1336166
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