Reactome | phospho-Pxn [cytosol]

phospho-Pxn [cytosol]

Stable Identifier

R-MMU-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y31,Y118-PXN, Q8VI36

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by PTK6 (Mus musculus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
      - Activation of RAC1 by the PXN:CRK complex (Mus musculus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - PTK6 phosphorylates PXN (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - Phosphorylated PXN recruits the CRK complex (Mus musculus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - CRK binds BCAR1 and or PXN (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - DOCK180:ELMO binds CRK (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8VI36

Gene Names

Pxn

Reference Genes

BioGPS Gene:19303 Pxn

ENSEMBL:ENSMUSG00000029528

ENSEMBL:ENSMUSG00000029528 Pxn

KEGG Gene (Mus musculus):19303 Pxn

Monarch:19303 Pxn

NCBI Gene:19303 Pxn

UCSC:Q8VI36 Pxn

Reference Transcript

Other Identifiers

103398_at

10524703

1424027_at

1426085_a_at

1456135_s_at

17441168

19303

4416900

4488491

4696196

4707523

4814186

4880634

4918436

5072706

5219942

5383193

5387860

5435199

5439568

5466402

5479212

5498596

5557398

5596839

5605911

5614653

A_51_P214859

A_52_P532973

GE119263

GE127603

GO:0001725

GO:0003712

GO:0005078

GO:0005178

GO:0005515

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005925

GO:0005938

GO:0006351

GO:0006354

GO:0007010

GO:0007155

GO:0007160

GO:0007179

GO:0007229

GO:0008013

GO:0008092

GO:0008360

GO:0017166

GO:0018108

GO:0019901

GO:0019903

GO:0023052

GO:0030027

GO:0030032

GO:0030154

GO:0030159

GO:0031252

GO:0034330

GO:0034446

GO:0036211

GO:0038191

GO:0043226

GO:0043410

GO:0043542

GO:0044877

GO:0045766

GO:0045860

GO:0046872

GO:0048041

GO:0048754

GO:0048856

GO:0048870

GO:0051435

GO:0051496

GO:0060090

GO:0060396

GO:0070161

GO:1901652

ILMN_1225102

ILMN_2460293

ILMN_3123303

mMC011168

Participates

as a component of

as an input of

Phosphorylated PXN recruits the CRK complex (Mus musculus)

as an output of

PTK6 phosphorylates PXN (Mus musculus)

Other forms of this molecule

Pxn [plasma membrane]

phospho-Pxn [plasma membrane]

Pxn [cytosol]

Inferred From

p-Y31,Y118-PXN [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31 (in Homo sapiens)

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118 (in Homo sapiens)

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_598676.2, NP_035353.1

Ensembl

ENSMUST00000067268, ENSMUSP00000069624, ENSMUSG00000029528

PRO

Q8VI36

MGI

108295

PDB

6JMU, 5W93

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34152 Ptk2	13	phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) PTK2 [cytosol] (R-MMU-201621) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-pY-PTK2 [cytosol] (R-MMU-9632393) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600)	0.784	6
UniProt:Q64727	5	Vcl [specific granule lumen] (R-MMU-6799711) Vcl [secretory granule lumen] (R-MMU-6801010) Vcl [extracellular region] (R-MMU-350736) Vcl [ficolin-1-rich granule lumen] (R-MMU-6800985) Vcl [cytosol] (R-MMU-350753)	0.537	3

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