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p130Cas binds Fak
Stable Identifier
R-MMU-5218849
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SBML
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BioPAX
Level 2
Level 3
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PDF
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PPTX
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SBGN
P130CAS (Crk-associated substrate/BCAR1) is an adaptor protein which upon phosphorylation recruits additional signaling proteins that link the scaffold to the actin cytoskeleton of the cell (Klemke at al. 1998). The C-terminal proline-rich region of Focal adhesion kinase (FAK1) spanning amino acids 712-718 binds the SH3 domain-containing region of p130CAS (Polte & Hanks 1995). P130CAS also interacts with Src-family kinases (SFKs) via its C-terminal Src-binding domain (SBD). Though FAK1 has no tyrosine kinase activity towards p130CAS, it contributes to p130CAS phosphorylation by interacting with SFKs (Ruest et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
11604500
Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src
Zhang, X
,
Polte, TR
,
Shin, NY
,
Ruest, PJ
,
Hanks, SK
Mol. Cell. Biol.
2001
7479864
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas
Polte, TR
,
Hanks, SK
Proc. Natl. Acad. Sci. U.S.A.
1995
Participants
Input
Fak1 [cytosol]
(Mus musculus)
p130Cas [cytosol]
(Mus musculus)
Output
Fak1:p130Cas [cytosol]
(Mus musculus)
Orthologous Events
BCAR1 binds p-7Y-PTK2 (Homo sapiens)
Authored
Garapati, P V (2013-08-30)
Reviewed
Ballmer-Hofer, K (2014-05-12)
Welsh, M (2014-05-12)
Berger, P (2014-05-12)
Created
Garapati, P V (2013-12-19)
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