Reactome | Setd1b [nucleoplasm]

Setd1b [nucleoplasm]

Stable Identifier

R-MMU-5244714

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

SETD1B, Q8CFT2

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- Epigenetic regulation of gene expression (Mus musculus)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Mus musculus)
    - Formation of WDR5-containing histone-modifying complexes (Mus musculus)
      - CXXC1 and WDR82 bind SET1B complex (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        SET1B complex:WDR82:CXXC1 [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
      - Formation of the SET1B complex (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX1 (Mus musculus)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Core MLL complex [nucleoplasm] (Mus musculus)
        
        SET1B complex [nucleoplasm] (Mus musculus)
        
        Setd1b [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CFT2

Gene Names

Setd1b

Reference Genes

BioGPS Gene:208043 Setd1b

ENSEMBL:ENSMUSG00000038384

KEGG:mmu:208043 Setd1b

Monarch:208043 Setd1b

NCBI Gene:208043 Setd1b

UCSC:Q8CFT2 Setd1b

Reference Transcript

RefSeq:NM_001040398.2 Setd1b

Other Identifiers

10525489

10525495

129315_at

1437353_at

1440836_at

17442203

208043

4317182

4319977

4321737

4359324

4378235

4400885

4412056

4422149

4439213

4481818

4493244

4515654

4518457

4559483

4636434

4668516

4713213

4750002

4771988

4799294

4824801

4909355

4932042

4938252

4970116

4993974

5002400

5025495

5035040

5080313

5113947

5116839

5142033

5189953

5250499

5260294

5263145

5335585

5348979

5381236

5402529

5489734

5531330

5541875

5555866

A_51_P275469

A_52_P303407

A_52_P468033

A_55_P2003199

A_55_P2719709

A_55_P2726469

GE116029

GO:0003676

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0008168

GO:0016607

GO:0016740

GO:0032259

GO:0035097

GO:0042800

GO:0048188

GO:0140096

GO:0140945

GO:0140999

ILMN_1258086

mMC012244

Participates

as a member of

SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm] (Mus musculus)

as an input of

Formation of the SET1B complex (Mus musculus)

as a component of

SET1B complex [nucleoplasm] (Mus musculus)

Inferred From

SETD1B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001035488.2

ENSEMBL

ENSMUSP00000133933, ENSMUST00000174836, ENSMUST00000056053, ENSMUSP00000134461, ENSMUST00000163030, ENSMUSP00000134686, ENSMUSG00000038384

IntEnz

2.1.1.364

PRO

Q8CFT2

GlyGen

Q8CFT2

MGI

2652820

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