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Apc [cytosol]
Stable Identifier
R-MMU-5246690
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
K63polyUb-APC, Q61315
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ovarian tumor domain proteases (Mus musculus)
ZRANB1 binds APC (Mus musculus)
Apc [cytosol] (Mus musculus)
ZRANB1:K63polyUb-APC [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by WNT (Mus musculus)
Degradation of beta-catenin by the destruction complex (Mus musculus)
AXIN is phosphorylated in the destruction complex (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Assembly of the destruction complex (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Association of beta-catenin with the destruction complex (Mus musculus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Beta-catenin phosphorylation cascade (Mus musculus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Mus musculus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
Phosphorylation of APC component of the destruction complex (Mus musculus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
ZRANB1 binds APC (Mus musculus)
Apc [cytosol] (Mus musculus)
ZRANB1:K63polyUb-APC [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Mus musculus)
Beta-catenin is released from the destruction complex (Mus musculus)
Apc [cytosol] (Mus musculus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Apc [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q61315
Gene Names
Apc
Reference Genes
ENSEMBL:ENSMUSG00000005871
Participates
as an input of
ZRANB1 binds APC (Mus musculus)
Assembly of the destruction complex (Mus musculus)
as a component of
ZRANB1:K63polyUb-APC [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
as an output of
Beta-catenin is released from the destruction complex (Mus musculus)
Other forms of this molecule
Apc [nucleoplasm]
phospho-Apc [cytosol]
Apc [cytosol]
Apc [cytosol]
Apc [cytosol]
Inferred From
K63polyUb-APC [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
PRO
Q61315
MGI
88039
PDB
1VJ6
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