Havcr2 binds Lgals9

Stable Identifier
R-MMU-5340404
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Havcr2 binds Lgals9

T-helper (Th) cell-mediated immunity is required to eliminate pathogens effectively but unrestrained Th activity can contribute to tissue damage in many inflammatory and autoimmune diseases. The T-cell immunoglobulin and mucin domain-containing protein (Havcr2, Tim3) inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and allo-immune responses and promotes immunological tolerance when it binds to its ligand, galectin-9 (Lgals9). The Havcr2:Lgals9 achieves this inhibition by inducing apoptosis of Th1 cells (Sanchez-Fueyo et al. 2003, Zhu et al. 2005).

Literature References
PubMed ID Title Journal Year
16286920 The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

Zhu, C, Anderson, AC, Schubart, A, Xiong, H, Imitola, J, Khoury, SJ, Zheng, XX, Strom, TB, Kuchroo, VK

Nat. Immunol. 2005
14556005 Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance

Sánchez-Fueyo, A, Tian, J, Picarella, D, Domenig, C, Zheng, XX, Sabatos, CA, Manlongat, N, Bender, O, Kamradt, T, Kuchroo, VK, Gutiérrez-Ramos, JC, Coyle, AJ, Strom, TB

Nat. Immunol. 2003
Participants
Orthologous Events
Authored
Reviewed
Created
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