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VCP hexamer [cytosol]
Stable Identifier
R-MMU-5362364
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Mus musculus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Mus musculus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)
Deglycosylation complex [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
Neddylation (Mus musculus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Mus musculus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Hedgehog (Mus musculus)
Hedgehog ligand biogenesis (Mus musculus)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Mus musculus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Mus musculus)
ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Mus musculus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)
ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
VCP hexamer [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
VCP [cytosol]
(Mus musculus)
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Mus musculus)
ERAD complex [endoplasmic reticulum membrane] (Mus musculus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Mus musculus)
Deglycosylation complex [endoplasmic reticulum membrane] (Mus musculus)
Inferred From
VCP hexamer [cytosol]
(Homo sapiens)
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