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phospho-Stat3 [cytosol]
Stable Identifier
R-MMU-539048
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-Y705,S727-STAT3, P42227
Locations in the PathwayBrowser for interactor UniProt:P48025 Syk
Expand all
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
STAT3 is phosphorylated downstream of active ALK (Mus musculus)
phospho-Stat3 [cytosol] (Mus musculus)
p-Y705,S727-STAT3 dimerizes (Mus musculus)
phospho-Stat3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P42227 Stat3
Gene Names
Stat3, Aprf
Chain
initiator methionine:, chain:2-770
Reference Genes
BioGPS Gene:20848 Stat3
KEGG:mmu:20848 Stat3
Monarch:20848 Stat3
NCBI Gene:20848 Stat3
UCSC:P42227 Stat3
Reference Transcript
RefSeq:NM_213660.3 Stat3
RefSeq:NM_213659.3 Stat3
Other Identifiers
10391301
1426587_a_at
1460700_at
17269717
20848
4309728
4314951
4400912
4433360
4438994
4444418
4468798
4479961
4481009
4481594
4516026
4550236
4618361
4677664
4679042
4728349
4759035
4824535
4867037
4898482
4900043
4904562
4910817
4921230
4940799
4958931
5058258
5069598
5088448
5141613
5143533
5157405
5179940
5182064
5182147
5202616
5219551
5235738
5237856
5343169
5364019
5378195
5387158
5411533
5473808
5483912
5522241
5557325
99099_at
99100_at
A_51_P201480
A_52_P569499
A_55_P1991219
GE119376
GE33020
GE38473
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001659
GO:0002376
GO:0002931
GO:0003677
GO:0003700
GO:0003723
GO:0004879
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005743
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006952
GO:0006953
GO:0006954
GO:0007005
GO:0007165
GO:0007179
GO:0007259
GO:0008283
GO:0008284
GO:0008285
GO:0010467
GO:0010507
GO:0010575
GO:0010628
GO:0010629
GO:0010730
GO:0014069
GO:0016071
GO:0016310
GO:0019221
GO:0019901
GO:0019903
GO:0019953
GO:0022414
GO:0030154
GO:0030335
GO:0030522
GO:0031490
GO:0031730
GO:0032355
GO:0032731
GO:0032733
GO:0032755
GO:0032757
GO:0032760
GO:0032870
GO:0032991
GO:0033210
GO:0034097
GO:0035019
GO:0035259
GO:0035591
GO:0035723
GO:0038110
GO:0038113
GO:0038154
GO:0038155
GO:0040014
GO:0042127
GO:0042593
GO:0042755
GO:0042789
GO:0042802
GO:0042803
GO:0043226
GO:0043434
GO:0043491
GO:0043565
GO:0044320
GO:0044321
GO:0045648
GO:0045747
GO:0045766
GO:0045820
GO:0045893
GO:0045944
GO:0046902
GO:0046983
GO:0048708
GO:0050728
GO:0050804
GO:0051726
GO:0055091
GO:0060019
GO:0060089
GO:0060090
GO:0060221
GO:0060259
GO:0060396
GO:0060397
GO:0061024
GO:0061629
GO:0070102
GO:0070878
GO:0071345
GO:0071407
GO:0072538
GO:0072540
GO:0090575
GO:0097009
GO:0097398
GO:0097696
GO:0098685
GO:0098978
GO:0099527
GO:0106015
GO:0106222
GO:0140033
GO:0140105
GO:0140110
GO:0140297
GO:0140313
GO:0140610
GO:1900017
GO:1900037
GO:1902728
GO:1902895
GO:1905564
GO:2000635
GO:2000737
GO:2001171
GO:2001223
ILMN_2589790
ILMN_2698046
ILMN_3096144
aa396029_s_at
mMC021060
mMR029005
u06922_s_at
Participates
as an input of
p-Y705,S727-STAT3 dimerizes (Mus musculus)
as a component of
p-Y705,S727-STAT3 dimer [cytosol] (Mus musculus)
as an output of
STAT3 is phosphorylated downstream of active ALK (Mus musculus)
as a member of
Tyrosine/serine phosphorylated STAT1, STAT3 [cytosol] (Mus musculus)
Other forms of this molecule
phospho-Stat3 [nucleoplasm]
phospho-Stat3 [cytosol]
Stat3 [cytosol]
phospho-Stat3 [cytosol]
Stat3 [cytosol]
p-Y705-Stat3 [cytosol]
p(Y705)-Stat3 [nucleoplasm]
phospho-Stat3 [nucleoplasm]
phospho-Stat3 [nucleoplasm]
phospho-Stat3 [nucleoplasm]
phospho-Stat3 [cytosol]
phospho-Stat3 [nucleoplasm]
Inferred From
p-Y705,S727-STAT3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 727 (in Homo sapiens)
Coordinate
727
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 705 (in Homo sapiens)
Coordinate
705
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_998825.1
,
NP_998824.1
ENSEMBL
ENSMUSP00000090342
,
ENSMUST00000127638
,
ENSMUST00000092671
,
ENSMUST00000103114
,
ENSMUSP00000120152
,
ENSMUSP00000099403
ZINC - Substances
STAT3_MOUSE
ZINC target
P42227
PRO
P42227
MGI
103038
GlyGen
P42227
ZINC - Predictions - Purchasable
STAT3_MOUSE
PDB
4E68
,
3CWG
,
1BG1
,
4ZIA
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40189 IL6ST
2
p-Y-IL6ST [plasma membrane]
(R-HSA-8950439)
IL6ST [plasma membrane]
(R-HSA-448453)
0.656
4
UniProt:Q00175
3
monoSUMO1-K7,K388,K531-PGR [nucleoplasm]
(R-MMU-4341032)
PGR [cytosol]
(R-MMU-8948964)
PGR [nucleoplasm]
(R-MMU-3008952)
0.649
4
UniProt:O54784 Dapk3
1
Death-associated protein kinase 3 [cytosol]
(R-MMU-418772)
0.645
8
IntAct:EBI-6398447 IL17F
0.643
3
IntAct:EBI-4566324 IL17
0.643
4
UniProt:Foxp3 ENSMUSG00000039521
0.643
3
UniProt:P48025 Syk
8
p-Syk [cytosol]
(R-MMU-9676057)
phospho-p-Y-SYK [cytosol]
(R-MMU-9705732)
phospho-p-Y-SYK [plasma membrane]
(R-MMU-429432)
Syk [cytosol]
(R-MMU-442293)
p-Y348,Y352,Y525,Y526-Syk [cytosol]
(R-MMU-5621123)
phospho-p-6Y-SYK [cytosol]
(R-MMU-1861712)
phospho-p-Y348-SYK [cytosol]
(R-MMU-437953)
SYK [cytosol]
(R-MMU-58268)
0.611
5
UniProt:P42227 Stat3
13
phospho-Stat3 [nucleoplasm]
(R-MMU-1112554)
phospho-Stat3 [cytosol]
(R-MMU-914048)
Stat3 [cytosol]
(R-MMU-539044)
phospho-Stat3 [cytosol]
(R-MMU-8983130)
Stat3 [cytosol]
(R-MMU-914084)
p-Y705-Stat3 [cytosol]
(R-MMU-914034)
p(Y705)-Stat3 [nucleoplasm]
(R-MMU-2730582)
phospho-Stat3 [cytosol]
(R-MMU-539048)
phospho-Stat3 [nucleoplasm]
(R-MMU-9027589)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701429)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701435)
phospho-Stat3 [cytosol]
(R-MMU-8982823)
phospho-Stat3 [nucleoplasm]
(R-MMU-8983188)
0.609
3
UniProt:P23927
1
CRYAB [nucleoplasm]
(R-MMU-6806336)
0.608
3
UniProt:P70424
12
phospho-p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-MMU-8864084)
phospho-p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-MMU-8864090)
phospho-p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-MMU-8863841)
phospho-p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-MMU-8863836)
ERBB2 [plasma membrane]
(R-MMU-372889)
phospho-p-Y877-ERBB2 [plasma membrane]
(R-MMU-1810438)
phospho-p-Y-ERBB2 [plasma membrane]
(R-MMU-1678589)
phospho-p-Y,Y877-ERBB2 [plasma membrane]
(R-MMU-1810446)
phospho-p-6Y-ERBB2 [plasma membrane]
(R-MMU-1963569)
phospho-p-7Y-ERBB2 [plasma membrane]
(R-MMU-1248698)
phospho-p-6Y,Y1112-ERBB2 [plasma membrane]
(R-MMU-8864081)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane]
(R-MMU-8864079)
0.537
4
UniProt:P30084 ECHS1
17
ECHS1 [mitochondrial matrix]
(R-HSA-54125)
A2V ECHS1 [mitochondrial matrix]
(R-HSA-9916688)
T180A ECHS1 [mitochondrial matrix]
(R-HSA-9916687)
A238V ECHS1 [mitochondrial matrix]
(R-HSA-9916686)
A132T ECHS1 [mitochondrial matrix]
(R-HSA-9916665)
G195S ECHS1 [mitochondrial matrix]
(R-HSA-9916681)
K273E ECHS1 [mitochondrial matrix]
(R-HSA-9916680)
R54H ECHS1 [mitochondrial matrix]
(R-HSA-9916676)
I66T ECHS1 [mitochondrial matrix]
(R-HSA-9916659)
D150G ECHS1 [mitochondrial matrix]
(R-HSA-9916674)
A158D ECHS1 [mitochondrial matrix]
(R-HSA-9916689)
C225R ECHS1 [mitochondrial matrix]
(R-HSA-9916672)
N59S ECHS1 [mitochondrial matrix]
(R-HSA-9916684)
A138V ECHS1 [mitochondrial matrix]
(R-HSA-9916683)
E77Q ECHS1 [mitochondrial matrix]
(R-HSA-9916667)
F33S ECHS1 [mitochondrial matrix]
(R-HSA-9916682)
Q159R ECHS1 [mitochondrial matrix]
(R-HSA-9916666)
0.524
3
UniProt:Q64261
3
CDK6 [cytosol]
(R-MMU-68336)
CDK6 [nucleoplasm]
(R-MMU-141283)
phospho-p-T177-CDK6 [nucleoplasm]
(R-MMU-69628)
0.499
3
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.463
3
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