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FEN1 [nucleoplasm]
Stable Identifier
R-MMU-54745
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
P39749
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
S Phase (Mus musculus)
Synthesis of DNA (Mus musculus)
DNA strand elongation (Mus musculus)
Lagging Strand Synthesis (Mus musculus)
Processive synthesis on the lagging strand (Mus musculus)
Removal of the Flap Intermediate (Mus musculus)
Removal of remaining Flap (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
Chromosome Maintenance (Mus musculus)
Telomere Maintenance (Mus musculus)
Extension of Telomeres (Mus musculus)
Telomere C-strand (Lagging Strand) Synthesis (Mus musculus)
Processive synthesis on the C-strand of the telomere (Mus musculus)
Removal of the Flap Intermediate from the C-strand (Mus musculus)
Removal of remaining Flap from the C-strand (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Resolution of Abasic Sites (AP sites) (Mus musculus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Mus musculus)
PCNA-Dependent Long Patch Base Excision Repair (Mus musculus)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
POLB-Dependent Long Patch Base Excision Repair (Mus musculus)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
POLB-mediated DNA strand displacement synthesis (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through MMEJ (alt-NHEJ) (Mus musculus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
DNA Replication (Mus musculus)
Synthesis of DNA (Mus musculus)
DNA strand elongation (Mus musculus)
Lagging Strand Synthesis (Mus musculus)
Processive synthesis on the lagging strand (Mus musculus)
Removal of the Flap Intermediate (Mus musculus)
Removal of remaining Flap (Mus musculus)
FEN1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P39749
Reference Genes
ENSEMBL:ENSMUSG00000024742
Participates
as an input of
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)
as a component of
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Mus musculus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
as an output of
FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)
Inferred From
FEN1 [nucleoplasm]
(Homo sapiens)
Cross References
PRO
P39749
MGI
102779
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