Expression of Period-2 (Per2)

Stable Identifier
R-MMU-549409
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Expression of Period-2 (Per2)

The Period-2 (Per2) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. An noncanonical E-box element in the promoter of Per2 binds the Bmal1:Clock (Arntl:Clock) heterodimer, which confers circadian expression on Per2.

Literature References
PubMed ID Title Journal Year
9427249 Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM

Neuron 1997
15699353 A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

Yoo, SH, Ko, CH, Lowrey, PL, Buhr, ED, Song, EJ, Chang, S, Yoo, OJ, Yamazaki, S, Lee, C, Takahashi, JS

Proc Natl Acad Sci U S A 2005
19330005 CK2alpha phosphorylates BMAL1 to regulate the mammalian clock

Tamaru, T, Hirayama, J, Isojima, Y, Nagai, K, Norioka, S, Takamatsu, K, Sassone-Corsi, P

Nat Struct Mol Biol 2009
9619629 A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus

Takumi, T, Matsubara, C, Shigeyoshi, Y, Taguchi, K, Yagita, K, Maebayashi, Y, Sakakida, Y, Okumura, K, Takashima, N, Okamura, H

Genes Cells 1998
12865428 Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes

Oishi, K, Miyazaki, K, Kadota, K, Kikuno, R, Nagase, T, Atsumi, G, Ohkura, N, Azama, T, Mesaki, M, Yukimasa, S, Kobayashi, H, Iitaka, C, Umehara, T, Horikoshi, M, Kudo, T, Shimizu, Y, Yano, M, Monden, M, Machida, K, Matsuda, J, Horie, S, Todo, T, Ishida, N

J Biol Chem 2003
9428527 A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light

Albrecht, U, Sun, ZS, Eichele, G, Lee, CC

Cell 1997
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Summation

Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind E-box elements (consensus CACGTG) in the promoters of target genes. Two E-box elements separated by 6 bp are sufficient to confer circadian transcription on a reporter gene. The Per2 promoter has a noncanonical E-box and is regulated by Bmal1:Clock. Regulation by Bmal1:Npas2 has also been demonstrated, leading to the conclusion that Clock and Npas2 are at least partially redundant.

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