Expression of Nr1d1 (Rev-erba)

Stable Identifier
R-MMU-549505
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Expression of Nr1d1 (Rev-erba)

The Nr1d1 (Rev-erba) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The Nr1d1 promoter is regulated by the Bmal1:Clock (Arntl:Clock) heterodimer, therefore Nr1d1 shows circadian expression.

Literature References
PubMed ID Title Journal Year
12150932 The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

Preitner, N, Damiola, F, Lopez-Molina, L, Zakany, J, Duboule, D, Albrecht, U, Schibler, U

Cell 2002
15591021 The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker

Triqueneaux, G, Thenot, S, Kakizawa, T, Antoch, MP, Safi, R, Takahashi, JS, Delaunay, F, Laudet, V

J Mol Endocrinol 2004
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Regulator
Summation

Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind E-box elements (consensus CACGTG) in the promoters of target genes. Two E-box elements separated by 6 bp are sufficient to confer circadian transcription on a reporter gene. The Rev-erba (Nr1d1) promoter has an E-box and is regulated by Bmal1:Clock. Regulation by Bmal1:Npas2 has also been demonstrated, leading to the conclusion that Clock and Npas2 are at least partially redundant.

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