Reactome | Ezh2 [nucleoplasm]

Ezh2 [nucleoplasm]

Stable Identifier

R-MMU-5617899

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase EZH2 ecNumber2.1.1.43/ecNumber, EZH2_MOUSE

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q61188 Ezh2

Gene Names

Ezh2, Enx1h

Chain

chain:1-746

Reference Genes

BioGPS Gene:14056 EZH2

KEGG:mmu:14056 EZH2

Monarch:14056 EZH2

NCBI Gene:14056 EZH2

UCSC:Q61188 EZH2

Reference Transcript

RefSeq:NM_007971.2 EZH2

Participates

as a component of

as an input of

Formation of PRC2-EZH2 complex (Mus musculus)

Inferred From

EZH2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_031997.2

ENSEMBL

ENSMUST00000092648, ENSMUSP00000080419, ENSMUST00000081721, ENSMUSP00000090318, ENSMUSG00000029687

PRO

Q61188

GlyGen

Q61188

MGI

107940

PDB

2QXV

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q921E6 Eed	2	Eed [nucleoplasm] (R-MMU-5617986) Eed [nucleoplasm] (R-MMU-212278)	0.858	10
UniProt:Q80U70 Suz12	3	Suz12 [nucleoplasm] (R-MMU-4615932) Suz12 [nucleoplasm] (R-MMU-5617919) Suz12 [nucleoplasm] (R-MMU-212217)	0.803	10
UniProt:Q62315	1	Jarid2 [nucleoplasm] (R-MMU-2160949)	0.774	15
UniProt:Q9CWR8 Dnmt3l	1	Dnmt3l [nucleoplasm] (R-MMU-5334127)	0.632	10
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.591	5
UniProt:Hoxc12 ENSMUSG00000050328			0.564	2
UniProt:O09106 Hdac1	2	monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-MMU-4616030) Hdac1 [nucleoplasm] (R-MMU-573340)	0.527	5
UniProt:P13864 Dnmt1	3	monoSUMO1-K-DNMT1 [nucleoplasm] (R-MMU-4655353) Dnmt1 [nucleoplasm] (R-MMU-573310) DNMT1 [nucleoplasm] (R-MMU-212181)	0.527	3
UniProt:Q02395	1	Mtf2 [nucleoplasm] (R-MMU-5084119)	0.499	4
UniProt:O88508 Dnmt3a	3	monoSumo1-K-Dnmt3a [nucleoplasm] (R-MMU-4655411) Dnmt3a [nucleoplasm] (R-MMU-4655420) DNMT3A [nucleoplasm] (R-MMU-212287)	0.499	3
UniProt:Q99JB6	1	Foxp3 [nucleoplasm] (R-MMU-8865539)	0.471	2