Hoxb1 gene is transcribed

Stable Identifier
R-MMU-5617972
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hoxb1 gene is transcribed
The Hoxb1 gene is transcribed to yield mRNA (Marshall et al. 1994, Studer et al. 1994, Ogura and Evans 1995, Chiba et al. 1997, Di Rocco et al. 1997, Langston et al. 1997, Wendling et al. 2001, Huang et al. 2002, Roelen et al. 2002).
Hoxb1 is expressed in mesoderm and neurectoderm of primitive streak stage embryos and then becomes restricted to rhombomeres of the hindbrain (Murphy et al. 1989, Wilkinson et al. 1989, Bogue et al. 1996). Before rhombomere formation Hoxb1 is initially expressed in the region that becomes r3-7. After rhombomere formation Hoxb1 becomes restricted to r4 and is also observed in caudal mesoderm (Murphy et al. 1989, Arenkiel et al. 2003).
Literature References
PubMed ID Title Journal Year
9154799 Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells

Chiba, H, Chambon, P, Metzger, D, Clifford, J

Mol. Cell. Biol. 1997
15654074 MEIS C termini harbor transcriptional activation domains that respond to cell signaling

Featherstone, M, Rambaldi, I, Goh, SL, Huang, H, Bodner, C, Rastegar, M

J. Biol. Chem. 2005
7831297 Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation

Evans, RM, Ogura, T

Proc. Natl. Acad. Sci. U.S.A. 1995
7831296 A retinoic acid-triggered cascade of HOXB1 gene activation

Evans, RM, Ogura, T

Proc. Natl. Acad. Sci. U.S.A. 1995
8703472 Expression of Hoxb genes in the developing mouse foregut and lung

Vasavada, H, Jacobs, HC, Wilson, CM, Lou, LJ, Bogue, CW

Am. J. Respir. Cell Mol. Biol. 1996
12815623 Hoxb1 neural crest preferentially form glia of the PNS

Arenkiel, BR, Gaufo, GO, Capecchi, MR

Dev. Dyn. 2003
2571936 Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

Krumlauf, R, Boncinelli, E, Cook, M, Wilkinson, DG, Bhatt, S

Nature 1989
7916164 Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1

Krumlauf, R, Marshall, H, Pöpperl, H, Kuroiwa, A, Studer, M

Science 1994
7914354 A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

Krumlauf, R, Marshall, H, Pöpperl, H, Aparicio, S, Brenner, S, Kuroiwa, A, Studer, M

Nature 1994
9218805 Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex

Di Rocco, G, Mavilio, F, Zappavigna, V

EMBO J. 1997
21320481 Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning

Sae-Pang, JJ, Wang, XA, Fritzsch, B, Wong, EY, Mak, SS, Sham, MH, Ling, KW

Dev. Biol. 2011
12385756 Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse

Roelen, BA, Forlani, S, de Graaff, W, Deschamps, J

Mech. Dev. 2002
11891985 Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice

Gudas, LJ, Huang, D, Chen, SW

Dev. Dyn. 2002
8999919 Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis

Thompson, JR, Langston, AW, Gudas, LJ

J. Biol. Chem. 1997
2571087 Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain

Murphy, P, Davidson, DR, Hill, RE

Nature 1989
11493525 Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning

Wendling, O, Chambon, P, Mark, M, Ghyselinck, NB

Development 2001
11278854 The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function

Krumlauf, R, Gavalas, A, Di Rocco, G, Mavilio, F, Zappavigna, V, Pöpperl, H

J. Biol. Chem. 2001
Participants
Input
Output
This event is regulated
Positively by
Regulator
atRA:Rara,g:Rxra at active Hoxb1 chromatin [nucleoplasm] (Mus musculus)
Orthologous Events
HOXB1 gene is transcribed (Homo sapiens)
Authored
May, B  (2014-08-15)
Rezsohazy, R  (2015-11-15)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-16)
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