Hoxa2 gene is transcribed

Stable Identifier
R-MMU-5619418
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hoxa2 gene is transcribed
The Hoxa2 gene is transcribed to yield mRNA (Tan et al. 1992, Maconochie et al. 2001, Tumpel et al. 2007, Lampe et al. 2008, Tumpel et al. 2008). Hoxa2 mRNA is observed in rhombomere 2 and caudally through posterior hindbrain, spinal cord, larynx, lungs, vertebrae, sternum, and intestine (Tan et al. 1992). Hoxa2 mRNA is a target of the microRNA miR-3960 during osteoblast differentiation (Hu et al. 2011).
Literature References
PubMed ID Title Journal Year
21324897 A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation

Xia, ZY, Hu, R, Li, H, Zhou, HD, Xie, H, Yang, L, Chen, C, Luo, XH, Guo, LJ, Liu, W, Wu, XP

J. Biol. Chem. 2011
17113575 Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1

Wiedemann, LM, Blasi, F, Cambronero, F, Tümpel, S, Ferretti, E, Krumlauf, R

Dev. Biol. 2007
15033486 The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element

Lampe, X, Picard, JJ, Rezsohazy, R

Biochem. Biophys. Res. Commun. 2004
19104046 A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2

Wiedemann, LM, Cambronero, F, Tümpel, S, Sims, C, Krumlauf, R

Proc. Natl. Acad. Sci. U.S.A. 2008
1352886 Murine Hox-1.11 homeobox gene structure and expression

Kozak, CA, Nirenberg, M, Shao, X, Ferrante, J, Guo, V, Tan, DP, Nazarali, A

Proc. Natl. Acad. Sci. U.S.A. 1992
18417536 An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4

Rijli, FM, Remacle, S, Matis, C, Guiguen, A, Lampe, X, Samad, OA, Picard, JJ, Rezsohazy, R

Nucleic Acids Res. 2008
11336508 Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development

Krumlauf, R, Nonchev, S, Manzanares, M, Marshall, H, Maconochie, MK

Dev. Biol. 2001
Participants
Input
Output
This event is regulated
Positively by
Regulator
Hoxb1:Pbx1:Pknox1 at active Hoxa2 chromatin [nucleoplasm] (Mus musculus)
Regulator
Egr2 at active Hoxa2 chromatin [nucleoplasm] (Mus musculus)
Orthologous Events
HOXA2 gene is transcribed (Homo sapiens)
Authored
May, B  (2014-08-16)
Rezsohazy, R  (2015-11-15)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-22)
Cite Us!