Hoxb2 gene is transcribed

Stable Identifier
R-MMU-5619432
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hoxb2 gene is transcribed
The Hoxb2 gene is transcribed to yield mRNA (Rubock et al. 1990, Sham et al. 1993, Vesque et al. 1996, Maconochie et al. 1997, Jacobs et al. 1999, Ferretti et al. 2000, Maconochie et al. 2001, Ferrai et al. 2009). Hoxb2 mRNA is observed in rhombomere 3 and caudally in the neural tube and mesoderm derivatives such as lung (Rubock et al. 1990).
Literature References
PubMed ID Title Journal Year
8895582 Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site

Krumlauf, R, Nonchev, S, Maconochie, M, Ariza-McNaughton, L, Vesque, C, Charnay, P, Kuroiwa, A

EMBO J. 1996
19477923 Induction of HoxB transcription by retinoic acid requires actin polymerization

Blasi, F, Scita, G, Diaz, VM, Naum-Onganía, G, Crippa, MP, Palazzolo, M, Disanza, A, Ferrai, C, Longobardi, E

Mol. Biol. Cell 2009
8093858 The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation

Krumlauf, R, Nonchev, S, Marshall, H, Frain, M, Sham, MH, Vesque, C, Charnay, P, Gupta, RD, Wilkinson, D, Whiting, J

Cell 1993
9242495 Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1

Krumlauf, R, Nonchev, S, Sham, MH, Pöpperl, H, Maconochie, MK, Chan, SK, Mann, RS, Studer, M

Genes Dev. 1997
10654609 Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins

Krumlauf, R, Maconochie, M, Marshall, H, Blasi, F, Pöpperl, H, Ferretti, E

Development 2000
10373562 Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity

Cleary, ML, Jacobs, Y, Schnabel, CA

Mol. Cell. Biol. 1999
11336508 Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development

Krumlauf, R, Nonchev, S, Manzanares, M, Marshall, H, Maconochie, MK

Dev. Biol. 2001
1972280 A yeast artificial chromosome containing the mouse homeobox cluster Hox-2

Papalopulu, N, Lehrach, H, Krumlauf, R, Larin, Z, Cook, M, Rubock, MJ

Proc. Natl. Acad. Sci. U.S.A. 1990
Participants
Input
Output
This event is regulated
Positively by
Regulator
Hoxb1:Pbx1:Meis1 at active Hoxb2 chromatin [nucleoplasm] (Mus musculus)
Regulator
Egr2 at active Hoxb2 chromatin [nucleoplasm] (Mus musculus)
Orthologous Events
HOXB2 gene is transcribed (Homo sapiens)
Authored
May, B  (2014-08-16)
Rezsohazy, R  (2015-11-15)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-22)
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