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p-Y348,Y352,Y525,Y526-Syk [cytosol]
Stable Identifier
R-MMU-5621123
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Tyrosine-protein kinase SYK, KSYK_MOUSE, Syk
External Reference Information
External Reference
UniProt:P48025 Syk
Gene Names
Syk, ptk72, Sykb
Chain
chain:1-629
Reference Genes
BioGPS Gene:20963 Syk
ENSEMBL:ENSMUSG00000021457.15 Syk
KEGG Gene (Mus musculus):20963 Syk
Monarch:20963 Syk
NCBI Gene:20963 Syk
UCSC:P48025 Syk
Reference Transcript
RefSeq:XM_006516895.3 Syk
RefSeq:NM_001198977.1 Syk
RefSeq:NM_011518.2 Syk
Other Identifiers
100425_at
100426_s_at
10405216
1418261_at
1418262_at
1425797_a_at
17287381
20963
4364453
4461813
4476939
4520961
4579585
4654953
4665178
4868775
4870615
4885339
4950455
5103375
5150242
5191797
5211223
5236290
5292099
5583840
A_51_P444934
A_55_P1962946
A_66_P138936
GE36166
GO:0000166
GO:0001525
GO:0001775
GO:0001784
GO:0001819
GO:0001820
GO:0001945
GO:0002092
GO:0002223
GO:0002250
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0002696
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0007155
GO:0007159
GO:0007166
GO:0007167
GO:0007169
GO:0007186
GO:0007229
GO:0010543
GO:0010803
GO:0012501
GO:0016020
GO:0016170
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019370
GO:0019722
GO:0019815
GO:0019901
GO:0019902
GO:0019904
GO:0023052
GO:0030154
GO:0030183
GO:0030593
GO:0031234
GO:0031334
GO:0031410
GO:0031623
GO:0031625
GO:0032009
GO:0032481
GO:0032725
GO:0032733
GO:0032735
GO:0032752
GO:0032753
GO:0032755
GO:0032757
GO:0032760
GO:0032765
GO:0032928
GO:0032930
GO:0032991
GO:0033630
GO:0035325
GO:0035556
GO:0036211
GO:0038063
GO:0038156
GO:0042060
GO:0042101
GO:0042169
GO:0042492
GO:0042742
GO:0043226
GO:0043274
GO:0043303
GO:0043306
GO:0043313
GO:0043366
GO:0043410
GO:0045087
GO:0045335
GO:0045579
GO:0045588
GO:0045780
GO:0046638
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050731
GO:0050764
GO:0050776
GO:0050778
GO:0050850
GO:0050853
GO:0051649
GO:0051712
GO:0065003
GO:0070372
GO:0071226
GO:0071396
GO:0071404
GO:0071639
GO:0090237
GO:0090330
GO:0097110
GO:0098542
GO:0120162
GO:0140096
GO:1904263
GO:1990858
ILMN_1252460
mMC017992
z49877_s_at
Participates
as a component of
p-Y348,352,525,526-Syk:Plcg1 [cytosol] (Mus musculus)
as an input of
Plcg1 binds p-Y348,352,525,526-Syk (Mus musculus)
as a member of
Lyn, p-Syk [cytosol] (Mus musculus)
Other forms of this molecule
p-Syk [cytosol]
phospho-p-Y-SYK [cytosol]
phospho-p-Y-SYK [plasma membrane]
Syk [cytosol]
phospho-p-6Y-SYK [cytosol]
phospho-p-Y348-SYK [cytosol]
SYK [cytosol]
Modified Residues
Name
O4'-phospho-L-tyrosine at 348
Coordinate
348
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 352
Coordinate
352
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 525
Coordinate
525
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 526
Coordinate
526
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_006516958.1
,
NP_035648.2
,
NP_001185906.1
IntEnz
2.7.10.2
Ensembl
ENSMUST00000055087
,
ENSMUSP00000113852
,
ENSMUSP00000060828
,
ENSMUST00000120135
,
ENSMUSG00000021457
PRO
P48025
MGI
99515
PDB
2MC1
,
2LCT
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42227 Stat3
13
phospho-Stat3 [nucleoplasm]
(R-MMU-1112554)
phospho-Stat3 [cytosol]
(R-MMU-914048)
Stat3 [cytosol]
(R-MMU-539044)
Stat3 [cytosol]
(R-MMU-914084)
p-Y705-Stat3 [cytosol]
(R-MMU-914034)
p(Y705)-Stat3 [nucleoplasm]
(R-MMU-2730582)
phospho-Stat3 [cytosol]
(R-MMU-8983130)
phospho-Stat3 [nucleoplasm]
(R-MMU-9027589)
phospho-Stat3 [cytosol]
(R-MMU-539048)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701429)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701435)
phospho-Stat3 [cytosol]
(R-MMU-8982823)
phospho-Stat3 [nucleoplasm]
(R-MMU-8983188)
0.611
5
UniProt:Q64693 OBF1
0.544
2
IntAct:EBI-15720745 DPITAM
0.544
2
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.524
2
UniProt:P08487 PLCG1
0.462
4
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