Clec6a binds alpha-mannan in fungal cell walls

Stable Identifier
R-MMU-5621348
Type
Reaction [binding]
Species
Mus musculus
Related Species
Candida albicans
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Clec6a binds alpha-mannan in fungal cell walls
CLEC6A (C-type lectin domain family 6 member A/Dectin-2 (Dendritic cell-associated C-type lectin 2)) a C-type lectin expressed by dendritic cells (DCs) and activated macrophages has been shown to bind structures with high mannose content (McGreal et al. 2006). It is reported to recognise a variety of pathogens including Candida albicans, Saccharomyces cerevisiae, Mycobacterium tuberculosis, Paracoccidioides brasiliensis, Histoplasma capsulatum, Aspergillus fumigatus, non-encapsulated Cryptococcus neoformans, Microsporum audouinii, Trichophyton rubrum, Schistosoma mansoni and house dust mite allergens (Sato et al. 2006, Gorjestani et al. 2011, Ritter et al. 2010, McGreal et al. 2006, Kerscher et al. 2013).
Like other members of the Dectin-2 family, cytoplasmic region of CLEC6A has no obvious signalling motif and it associates with transmembrane adapter FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) to transduce a CLEC6A/Dectin-2 signalling.
Literature References
PubMed ID Title Journal Year
17050534 Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses

Yang, XL, Underhill, D, Kimberly, RP, Chung, JS, Sato, K, Luby-Phelps, K, Ariizumi, K, Cruz, PD, Wu, J, Yudate, T

J. Biol. Chem. 2006
Participants
Input
Output
Orthologous Events
CLEC6A binds alpha-mannan in fungal cell walls (Homo sapiens)
Authored
Garapati, P V  (2014-08-29)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-08-29)
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