Smurf1/2 ubiquitinates Ptch1

Stable Identifier
R-MMU-5632644
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Smurf1/2 ubiquitinates Ptch1
Mouse Ptch1 is ubiquitinated on its C-terminal tail in a Smurf1/2-dependent manner. Smurf1/2-mediated ubiquitination is stimulated by SHH and results in downregulation of Ptch1 from the ciliary membrane to endocytic compartments for degradation (Yue et al, 2014).
Literature References
PubMed ID Title Journal Year
24925320 Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception

Zhang, YE, Shen, QH, Tang, LY, Chen, Y, Yue, S, Zhang, Z, Tang, Y, Tang, Y, Ding, J, Cheng, SY, Yu, TT

Elife 2014
Participants
Input
Output
Catalyst Activity

ubiquitin protein ligase activity of Ptch1:Smurf1/2 [plasma membrane]

Physical Entity
Ptch1:Smurf1/2 [plasma membrane] (Mus musculus)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)
Authored
Rothfels, K  (2014-10-20)
Reviewed
Liu, Y C  (2014-11-09)
Created
Rothfels, K  (2014-10-28)
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