Reactome | Cenps [nucleoplasm]

Cenps [nucleoplasm]

Stable Identifier

R-MMU-5633510

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

APITD1, Q9D084

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Chromosome Maintenance (Mus musculus)
  - Nucleosome assembly (Mus musculus)
    - Deposition of new CENPA-containing nucleosomes at the centromere (Mus musculus)
      - HJURP:CENPA complex localizes to the centromere (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
      - Mis18 complex binds the centromere (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
      - RSF complex binds the centromere (Mus musculus)
        
        CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)

DNA Repair (Mus musculus)

- Fanconi Anemia Pathway (Mus musculus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Mus musculus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
    - FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Mus musculus)
      - APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - Monoubiquitination of FANCD2:FANCI (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Mus musculus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)
  - Translesion synthesis across unhooked ICL by POLN (Mus musculus)
    - p-FA Core Complex [nucleoplasm] (Mus musculus)
      - APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenps [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9D084

Gene Names

Cenps

Reference Genes

BioGPS Gene:69928 Cenps

ENSEMBL:ENSMUSG00000073705

ENSEMBL:ENSMUSG00000073705.11 Cenps

KEGG Gene (Mus musculus):69928 Cenps

Monarch:69928 Cenps

NCBI Gene:69928 Cenps

UCSC:Q9D084 Cenps

Reference Transcript

RefSeq:NM_027263.2 Cenps

Other Identifiers

10518561

115386_at

1453067_at

17433029

4368255

4428533

4582148

4730999

4827340

4832032

4884953

5265581

5354582

5422414

5529423

5588462

5592231

69928

A_51_P270519

A_52_P206058

GE123283

GO:0000712

GO:0000775

GO:0000776

GO:0000785

GO:0000939

GO:0003677

GO:0003682

GO:0003690

GO:0005634

GO:0005694

GO:0006260

GO:0006281

GO:0006310

GO:0006974

GO:0007049

GO:0007059

GO:0022414

GO:0031297

GO:0036297

GO:0043226

GO:0043240

GO:0046982

GO:0051301

GO:0071821

GO:0140013

ILMN_1231416

ILMN_2983714

mMC010883

Participates

as a component of

Other forms of this molecule

Cenps [cytosol]

Inferred From

APITD1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_081539.1

Ensembl

ENSMUST00000105695, ENSMUSP00000101320, ENSMUST00000030813, ENSMUSG00000073705, ENSMUSP00000030813

PRO

Q9D084

MGI

1917178

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