Reactome | Cenpx [nucleoplasm]

Cenpx [nucleoplasm]

Stable Identifier

R-MMU-5633522

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

STRA13, Q8C4X1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Chromosome Maintenance (Mus musculus)
  - Nucleosome assembly (Mus musculus)
    - Deposition of new CENPA-containing nucleosomes at the centromere (Mus musculus)
      - HJURP:CENPA complex localizes to the centromere (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
      - Mis18 complex binds the centromere (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
      - RSF complex binds the centromere (Mus musculus)
        
        CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Mus musculus)
        
        CCAN [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)

DNA Repair (Mus musculus)

- Fanconi Anemia Pathway (Mus musculus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Mus musculus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
    - FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Mus musculus)
      - APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - Monoubiquitination of FANCD2:FANCI (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        p-FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Mus musculus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Mus musculus)
        
        FA Core Complex [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)
  - Translesion synthesis across unhooked ICL by POLN (Mus musculus)
    - p-FA Core Complex [nucleoplasm] (Mus musculus)
      - APITD1:STRA13 octamer [nucleoplasm] (Mus musculus)
        
        APITD1:STRA13 [nucleoplasm] (Mus musculus)
        
        Cenpx [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8C4X1

Gene Names

Cenpx

Reference Genes

BioGPS Gene:20892 Cenpx

ENSEMBL:ENSMUSG00000025144

ENSEMBL:ENSMUSG00000025144.18 Cenpx

KEGG Gene (Mus musculus):20892 Cenpx

Monarch:20892 Cenpx

NCBI Gene:20892 Cenpx

UCSC:Q8C4X1 Cenpx

Reference Transcript

Other Identifiers

10393917

1416553_at

17273280

20892

4376460

4618670

4866363

5050797

5188366

5222940

5315003

5384828

5584472

A_52_P124429

A_55_P1967138

GO:0000712

GO:0000775

GO:0000776

GO:0000785

GO:0000939

GO:0003677

GO:0003690

GO:0005634

GO:0005694

GO:0006260

GO:0006281

GO:0006310

GO:0006974

GO:0007049

GO:0007059

GO:0022414

GO:0031297

GO:0036297

GO:0043226

GO:0043240

GO:0051301

GO:0051382

GO:0065003

GO:0071821

GO:0140013

ILMN_1237761

mMC012455

Participates

as a component of

Other forms of this molecule

Cenpx [cytosol]

Inferred From

STRA13 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001334540.1, NP_057874.2

Ensembl

ENSMUSG00000025144, ENSMUST00000026137, ENSMUSP00000026137, ENSMUSP00000050335, ENSMUST00000055424

PRO

Q8C4X1

MGI

894324

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