Reactome | POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]

POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]

Stable Identifier

R-MMU-5649885

Type

Complex

Species

Mus musculus

Compartment

nucleoplasm

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

APEX1 [nucleoplasm] (Mus musculus)
Ghost homologue of SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Mus musculus)
POLB [nucleoplasm] (Mus musculus)

Participates

as an input of

PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)

as an output of

POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)

Inferred From

POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)

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