Reactome | PAR-PARP1 [nucleoplasm]

PAR-PARP1 [nucleoplasm]

Stable Identifier

R-MMU-5651713

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

P11103

Locations in the PathwayBrowser

Expand all

DNA Repair (Mus musculus)

- Base Excision Repair (Mus musculus)
  - Resolution of Abasic Sites (AP sites) (Mus musculus)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Mus musculus)
      - POLB-Dependent Long Patch Base Excision Repair (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        PARG dePARylates PARP1,PARP2 (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)
        
        PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
- DNA Double-Strand Break Repair (Mus musculus)
  - Homology Directed Repair (Mus musculus)
    - HDR through MMEJ (alt-NHEJ) (Mus musculus)
      - PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
- Nucleotide Excision Repair (Mus musculus)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
    - DNA Damage Recognition in GG-NER (Mus musculus)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
    - Dual Incision in GG-NER (Mus musculus)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Mus musculus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
    - Formation of Incision Complex in GG-NER (Mus musculus)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Mus musculus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - CHD1L is recruited to GG-NER site (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - Formation of the pre-incision complex in GG-NER (Mus musculus)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - RNF111 ubiquitinates SUMOylated XPC (Mus musculus)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - Recruitment of XPA and release of CAK (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - SUMOylation of XPC (Mus musculus)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
      - TFIIH binds GG-NER site to form a verification complex (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Mus musculus)
        
        PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
        
        PAR-PARP1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P11103

Reference Genes

ENSEMBL:ENSMUSG00000026496

UCSC:P11103

Participates

as a member of

PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)

Other forms of this molecule

polySUMO2,3-K203,K486-PARP1 [nucleoplasm]

monoSUMO1-K203,K486-PARP1 [nucleoplasm]

PARP1 [nucleoplasm]

Inferred From

PAR-PARP1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

L-glutamyl-5-poly(ADP-ribose) at unknown position

PsiMod Name

L-glutamyl-5-poly(ADP-ribose)

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose).

Cross References

ZINC - Substances

PARP1_MOUSE

ZINC target

P11103

PRO

P11103

GlyGen

P11103

MGI

1340806

ZINC - Predictions - Purchasable

PARP1_MOUSE

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-11426955 1082A			0.524	3
UniProt:P03087 VP1			0.524	2
UniProt:P70288 Hdac2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-MMU-4615958) Hdac2 [nucleoplasm] (R-MMU-573366)	0.499	3
UniProt:P20263 Pou5f1	2	Pou5f1 [nucleoplasm] (R-MMU-3245981) POU5F1 [nucleoplasm] (R-MMU-452472)	0.499	2
UniProt:Q3TKT4 Smarca4	2	Smarca4 [nucleoplasm] (R-MMU-9727480) SMARCA4 [nucleoplasm] (R-MMU-201686)	0.499	2
UniProt:Q9WTL8 Arntl	4	Arntl [nucleoplasm] (R-MMU-9769624) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [cytosol] (R-MMU-508660) p-S-Arntl [nucleoplasm] (R-MMU-508690)	0.499	7

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