Reactome | RRAGC [cytosol]

RRAGC [cytosol]

Stable Identifier

R-MMU-5653949

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q99K70

Locations in the PathwayBrowser

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Autophagy (Mus musculus)

- Macroautophagy (Mus musculus)
  - Active MTORC1 binds the ULK1 complex (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Active MTORC1 phosphorylates ULK1 (Mus musculus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - MTORC1 dissociates from ULK complex (Mus musculus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to starvation (Mus musculus)
    - Amino acids regulate mTORC1 (Mus musculus)
      - RRAGA,B exchanges GDP for GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RRAGA,B:GDP:RRAGC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - RRAGA,B hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RRAGA,B:GDP:RRAGC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - RRAGC,D exchanges GTP for GDP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RRAGA,B:GDP:RRAGC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GDP:RagC,D:GTP [cytosol] (Mus musculus)
        
        RRAGC,D:GTP [cytosol] (Mus musculus)
        
        RRAGC:GTP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - RRAGC,D hydrolyzes GTP (Mus musculus)
        
        RRAGC,D:GTP [cytosol] (Mus musculus)
        
        RRAGC:GTP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RRAGA,B:GDP:RRAGC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GDP:RagC,D:GTP [cytosol] (Mus musculus)
        
        RRAGC,D:GTP [cytosol] (Mus musculus)
        
        RRAGC:GTP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - mTORC1 binds RHEB:GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RRAGA,B:GDP:RRAGC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RRAGA,B:GDP:RRAGC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Metabolic Genes (Mus musculus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        MAF1 translocates to the nucleus (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
        
        mTORC1 phosphorylates MAF1 (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
- MTOR signalling (Mus musculus)
  - AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Mus musculus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Formation of active mTORC1 complex (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Rag dimer formation (Mus musculus)
    - RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
      - RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
      - RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Ragulator binds Rag dimers (Mus musculus)
    - RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
      - RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
      - RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - SLC38A9 binds Ragulator:Rag dimers (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
      - RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - mTORC1 phosphorylates AKT1S1 (Mus musculus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
  - mTORC1-mediated signalling (Mus musculus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        RagA,B:GTP:RagC,D:GDP [cytosol] (Mus musculus)
        
        RRAGC,RRAGD:GDP [cytosol] (Mus musculus)
        
        RRAGC:GDP [cytosol] (Mus musculus)
        
        RRAGC [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q99K70

Reference Genes

BioGPS Gene:54170

ENSEMBL:ENSMUSG00000028646

ENSEMBL:ENSMUSG00000028646.17

KEGG Gene (Mus musculus):54170

Monarch:54170

NCBI Gene:54170

UCSC:Q99K70

Reference Transcript

RefSeq:NM_017475.2

Other Identifiers

10338085

10339348

10339707

10339956

10340306

10340993

10341939

10342263

10343887

10343942

10344505

10344512

10507894

1415749_a_at

17208823

17208825

17208827

17418252

4335815

4565894

4571797

4599494

4718530

4870579

4916547

4973267

4996158

5069391

5076261

5097959

5262779

5266159

5295840

5400137

5402370

54170

5578934

5595201

98950_at

A_51_P346826

A_52_P202725

A_55_P2517274

GE37190

GO:0000166

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0006914

GO:0009267

GO:0010507

GO:0016020

GO:0016787

GO:0019003

GO:0023052

GO:0031669

GO:0032006

GO:0032008

GO:0034198

GO:0043200

GO:0043226

GO:0043231

GO:0043495

GO:0046982

GO:0051020

GO:0060090

GO:0061462

GO:0072657

GO:0140767

GO:1903432

GO:1904263

GO:1990131

GO:1990877

ILMN_2770414

mMC024249

Participates

as a component of

Inferred From

RRAGC [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_059503.2

Ensembl

ENSMUSP00000115232, ENSMUSG00000028646, ENSMUST00000155757, ENSMUST00000030399, ENSMUSP00000030399

PRO

Q99K70

MGI

1858751

PDB

5X6V

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