p-Bmal1:p-Clock,Npas2 binds Cry1 gene

Stable Identifier
Reaction [binding]
Mus musculus
SVG |   | PPTX  | SBGN
p-Bmal1:p-Clock,Npas2 binds Cry1 gene

Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind E-box elements (consensus CACGTG) in the promoters of target genes. Two E-box elements separated by 6 bp are sufficient to confer circadian transcription on a reporter gene. The Cryptochrome-1 (Cry1) promoter has an E-box and is regulated by Bmal1:Clock. Regulation by Bmal1:Npas2 is inferred from the redundancy of Clock and Npas2.

Literature References
PubMed ID Title Journal Year
19150926 Cry1 circadian phase in vitro: wrapped up with an E-box

Hastings, MH, Dardente, H, Hazlerigg, DG, Fustin, JM, O'Neill, JS

J Biol Rhythms 2009
10428031 mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

Kume, K, Zylka, MJ, Hastings, MH, Reppert, SM, Maywood, ES, Shearman, LP, Jin, X, Sriram, S, Weaver, DR

Cell 1999
17417633 CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Reppert, SM, DeBruyne, JP, Weaver, DR

Nat Neurosci 2007
16507766 Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation

Antoch, MP, Kondratova, AA, Gorbacheva, VY, Shamanna, RK, Kondratov, RV

FASEB J 2006
12483227 Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

Wade, PA, Reppert, SM, Lee, C, Etchegaray, JP

Nature 2003
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