p-Bmal1:p-Clock,Npas2 binds Nr1d1 gene

Stable Identifier
R-MMU-5663147
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
p-Bmal1:p-Clock,Npas2 binds Nr1d1 gene

Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind E-box elements (consensus CACGTG) in the promoters of target genes. Two E-box elements separated by 6 bp are sufficient to confer circadian transcription on a reporter gene. The Rev-erba (Nr1d1) promoter has an E-box and is regulated by Bmal1:Clock. Regulation by Bmal1:Npas2 has also been demonstrated, leading to the conclusion that Clock and Npas2 are at least partially redundant.

Literature References
PubMed ID Title Journal Year
15591021 The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker

Antoch, MP, Kakizawa, T, Safi, R, Laudet, V, Triqueneaux, G, Delaunay, F, Takahashi, JS, Thenot, S

J Mol Endocrinol 2004
12150932 The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

Albrecht, U, Schibler, U, Preitner, N, Zakany, J, Damiola, F, Duboule, D, Lopez-Molina, L

Cell 2002
17417633 CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Reppert, SM, DeBruyne, JP, Weaver, DR

Nat Neurosci 2007
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