Expression of Npas2

Stable Identifier
R-MMU-5663263
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Npas2
The Npas2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of Npas2 is enhanced by the Rora:Coactivator complex and repressed by the Nr1d1 (Rev-Erba):Corepressor complex.
Literature References
PubMed ID Title Journal Year
17476214 Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

Liu, T, Lin, JD, Li, S, Borjigin, J, Liu, C

Nature 2007
20817722 Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene

Kojetin, DJ, Crumbley, C, Burris, TP, Wang, Y

J Biol Chem 2010
15199055 RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

Parton, RG, Nixon, SJ, Lau, P, Muscat, GE

J Biol Chem 2004
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Nr1d1:heme:Corepressors:Npas2 gene [nucleoplasm] (Mus musculus)
Positively by
Regulator
Rora:Ep300:Npas2 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of NPAS2 (Homo sapiens)
Authored
May, B  (2015-01-16)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2015-01-17)
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