Expression of Clock

Stable Identifier
R-MMU-5667072
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Clock
The Clock gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The promoter of the Clock gene contains a RRe element that confers circadian expression, possibly through binding Rora or Rev-erba.
Literature References
PubMed ID Title Journal Year
17994338 Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice

Chan, P, Sothern, RB, Guan, Y, Liu, S, Cai, Y

Chronobiol Int 2007
15665827 System-level identification of transcriptional circuits underlying mammalian circadian clocks

Hayashi, S, Hashimoto, S, Iino, M, Chen, W, Machida, M, Shigeyoshi, Y, Ueda, HR, Sano, M

Nat. Genet. 2005
18815372 Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock

Hogenesch, JB, Nishio, J, Ueda, HR, Uno, KD, Masumoto, KH, Nagano, M, Kumaki, Y, Shigeyoshi, Y, Komori, T, Ukai-Tadenuma, M

Proc Natl Acad Sci U S A 2008
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Nr1d1:heme:Corepressors:Clock gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of CLOCK (Homo sapiens)
Authored
May, B  (2015-01-23)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2015-01-23)
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