Reactome | phospho-p-S311,Y602 KSR1 [plasma membrane]

phospho-p-S311,Y602 KSR1 [plasma membrane]

Stable Identifier

R-MMU-5672659

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Q61097

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Dissociation of RAS:RAF complex (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        RAF phosphorylates MAP2K dimer (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)
      - RAF activation (Mus musculus)
        
        Phosphorylation of RAF (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)
        
        phospho-p-S311,Y602 KSR1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q61097

Reference Genes

BioGPS Gene:16706

ENSEMBL:ENSMUSG00000018334

ENSEMBL:ENSMUSG00000018334.19

KEGG Gene (Mus musculus):16706

Monarch:16706

NCBI Gene:16706

UCSC:Q61097

Reference Transcript

Other Identifiers

10388914

117128_at

1419823_s_at

1450114_at

16706

17266534

4353954

4384997

4389876

4482449

4519878

4585955

4680703

4688210

4703865

4838946

4998697

5027654

5031293

5039608

5058447

5167029

5271013

5287882

5326132

5351235

5404598

5443883

5459002

5557908

5566794

5578492

5614283

92764_at

92765_s_at

A_52_P114414

A_52_P666855

A_55_P1973233

A_55_P1973238

GE36674

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0005078

GO:0005515

GO:0005524

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006468

GO:0007265

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019901

GO:0019933

GO:0023052

GO:0031434

GO:0032587

GO:0032991

GO:0036211

GO:0042127

GO:0042995

GO:0043226

GO:0043231

GO:0043405

GO:0043410

GO:0046872

GO:0051087

GO:0051879

GO:0060090

GO:0071889

GO:0106310

GO:0140096

ILMN_1254652

ILMN_2849036

U43585_s_at

mMC002142

Participates

as a component of

p-S311,T602 KSR1:MARK3 [plasma membrane] (Mus musculus)

Other forms of this molecule

phospho-p-S311,S406 KSR1 [cytosol]

KSR1 [cytosol]

phospho-p-S311 KSR1 [cytosol]

phospho-p-S311,Y602 KSR1 [cytosol]

Inferred From

p-S311,Y602 KSR1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 311 (in Homo sapiens)

Coordinate

311

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 602 (in Homo sapiens)

Coordinate

602

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006532398.1, NP_038599.1, NP_001335136.1

Ensembl

ENSMUSG00000018334, ENSMUST00000018478, ENSMUSP00000018478

PRO

Q61097

MGI

105051

PDB

1KBE, 1KBF, 2LPE

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.632	3
UniProt:P63101 Ywhaz	3	14-3-3zeta [cytosol] (R-MMU-206177) Ywhaz [nucleoplasm] (R-MMU-450469) Ywhaz [cytosol] (R-MMU-206099)	0.547	2
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.508	2
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.508	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.499	3

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