Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-Raf1 [plasma membrane]
Stable Identifier
R-MMU-5672665
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
p-S338,Y341,T491,S494,S621 RAF1, Q99N57
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
Negative feedback regulation of MAPK pathway (Mus musculus)
Activated MAPK phosphorylates RAF1 (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
PEBP1 binds activated RAF1 (Mus musculus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
PP5 dephosphorylates RAF1 S338 (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
RAF activation (Mus musculus)
Phosphorylation of RAF (Mus musculus)
RAF activating kinases [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
activated RAF/KSR1 [plasma membrane] (Mus musculus)
phospho-Raf1 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q99N57
Gene Names
Raf1
Reference Genes
BioGPS Gene:110157 Raf1
ENSEMBL:ENSMUSG00000000441
KEGG Gene (Mus musculus):110157 Raf1
Monarch:110157 Raf1
NCBI Gene:110157 Raf1
UCSC:Q99N57 Raf1
Reference Transcript
RefSeq:NM_029780.3 Raf1
RefSeq:XM_006505363.3 Raf1
RefSeq:XM_006505364.2 Raf1
RefSeq:XM_006505365.2 Raf1
Other Identifiers
10547034
110157
140282_f_at
1416078_s_at
1425419_a_at
17469894
4364488
4382407
4405510
4552942
4574845
4598310
4599262
4629137
4853093
4881848
4949521
4961361
5098067
5133730
5139630
5157830
5223962
5229250
5241129
5267873
5307983
5367810
5563343
5584314
5599575
5616693
94264_at
A_51_P404204
A_52_P214058
A_52_P412600
A_55_P1973643
GE125263
GO:0000165
GO:0000166
GO:0000186
GO:0001666
GO:0001678
GO:0001934
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005794
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007010
GO:0007165
GO:0007190
GO:0007267
GO:0007507
GO:0008150
GO:0008179
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0010856
GO:0015031
GO:0016020
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0019899
GO:0022607
GO:0030154
GO:0030234
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0031434
GO:0033138
GO:0034641
GO:0035019
GO:0035556
GO:0035773
GO:0035994
GO:0042592
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0044877
GO:0045104
GO:0045944
GO:0046872
GO:0048011
GO:0048538
GO:0048856
GO:0060324
GO:0065003
GO:0071550
GO:0106310
GO:0106311
GO:1902042
ILMN_2747229
Msa.24413.0_s_at
Msa.6334.0_s_at
mMC010690
Participates
as an input of
Activated MAPK phosphorylates RAF1 (Mus musculus)
as a candidate of
RAF activating kinases [plasma membrane] (Mus musculus)
as a component of
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
as a member of
activated RAF/KSR1 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-Raf1 [cytosol]
phospho-Raf1 [cytosol]
phospho-Raf1 [cytosol]
phospho-Raf1 [plasma membrane]
phospho-Raf1 [plasma membrane]
phospho-Raf1 [plasma membrane]
Raf1 [cytosol]
phospho-Raf1 [cytosol]
phospho-Raf1 [cytosol]
Inferred From
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341 (in Homo sapiens)
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338 (in Homo sapiens)
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491 (in Homo sapiens)
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494 (in Homo sapiens)
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_006505428.1
,
XP_006505427.1
,
XP_006505426.1
,
NP_084056.1
Ensembl
ENSMUST00000112949
,
ENSMUSP00000108571
,
ENSMUSG00000000441
,
ENSMUSP00000000451
,
ENSMUST00000000451
PRO
Q99N57
MGI
97847
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28028
6
Braf [cytosol]
(R-MMU-167224)
phospho-Braf [plasma membrane]
(R-MMU-5675199)
phospho-Braf [cytosol]
(R-MMU-5672667)
phospho-Braf [plasma membrane]
(R-MMU-5672679)
phospho-Braf [cytosol]
(R-MMU-5672673)
phospho-Braf [cytosol]
(R-MMU-5672676)
0.589
2
UniProt:Q8CFI0
2
Nedd4l [cytosol]
(R-MMU-976003)
Nedd4l [nucleoplasm]
(R-MMU-2176420)
0.524
2
UniProt:Q9Z2S7-3 TSC22D3
0.524
2
UniProt:P01111 NRAS
20
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
NRAS [plasma membrane]
(R-HSA-62725)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
0.499
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.499
3
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text