Reactome | phospho-Raf1 [plasma membrane]

phospho-Raf1 [plasma membrane]

Stable Identifier

R-MMU-5672665

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

p-S338,Y341,T491,S494,S621 RAF1, Q99N57

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Dissociation of RAS:RAF complex (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Mus musculus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        RAF phosphorylates MAP2K dimer (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
      - Negative regulation of MAPK pathway (Mus musculus)
        
        Negative feedback regulation of MAPK pathway (Mus musculus)
        
        Activated MAPK phosphorylates RAF1 (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        PEBP1 binds activated RAF1 (Mus musculus)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Mus musculus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        PP5 dephosphorylates RAF1 S338 (Mus musculus)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
      - RAF activation (Mus musculus)
        
        Phosphorylation of RAF (Mus musculus)
        
        RAF activating kinases [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
        
        activated RAF/KSR1 [plasma membrane] (Mus musculus)
        
        phospho-Raf1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q99N57

Gene Names

Raf1

Reference Genes

BioGPS Gene:110157 Raf1

ENSEMBL:ENSMUSG00000000441

ENSEMBL:ENSMUSG00000000441 Raf1

KEGG Gene (Mus musculus):110157 Raf1

Monarch:110157 Raf1

NCBI Gene:110157 Raf1

UCSC:Q99N57 Raf1

Reference Transcript

Other Identifiers

10547034

110157

140282_f_at

1416078_s_at

1425419_a_at

17469894

4364488

4382407

4405510

4552942

4574845

4598310

4599262

4629137

4853093

4881848

4949521

4961361

5098067

5133730

5139630

5157830

5223962

5229250

5241129

5267873

5307983

5367810

5563343

5584314

5599575

5616693

94264_at

A_51_P404204

A_52_P214058

A_52_P412600

A_55_P1973643

GE125263

GO:0003674

GO:0004672

GO:0005524

GO:0006464

GO:0006468

GO:0007165

GO:0008150

GO:0016301

GO:0035556

GO:0043167

ILMN_2747229

Msa.24413.0_s_at

Msa.6334.0_s_at

mMC010690

Participates

as an input of

Activated MAPK phosphorylates RAF1 (Mus musculus)

as a candidate of

RAF activating kinases [plasma membrane] (Mus musculus)

as a component of

p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)

as a member of

activated RAF/KSR1 [plasma membrane] (Mus musculus)

Other forms of this molecule

phospho-Raf1 [cytosol]

phospho-Raf1 [plasma membrane]

phospho-Raf1 [cytosol]

phospho-Raf1 [plasma membrane]

phospho-Raf1 [cytosol]

Raf1 [cytosol]

Inferred From

p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 621 (in Homo sapiens)

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 341 (in Homo sapiens)

Coordinate

341

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-serine at 338 (in Homo sapiens)

Coordinate

338

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 491 (in Homo sapiens)

Coordinate

491

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 494 (in Homo sapiens)

Coordinate

494

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_084056.1, XP_006505427.1, XP_006505426.1, XP_006505428.1

Ensembl

ENSMUSP00000000451, ENSMUSG00000000441, ENSMUSP00000108571, ENSMUST00000000451, ENSMUST00000112949

PRO

Q99N57

MGI

97847

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.643	4
UniProt:P28028	6	phospho-Braf [cytosol] (R-MMU-5672667) Braf [cytosol] (R-MMU-167224) phospho-Braf [plasma membrane] (R-MMU-5675199) phospho-Braf [plasma membrane] (R-MMU-5672679) phospho-Braf [cytosol] (R-MMU-5672673) phospho-Braf [cytosol] (R-MMU-5672676)	0.589	2
UniProt:Q9Z2S7-3 TSC22D3			0.524	2
UniProt:Q8CFI0	2	Nedd4l [nucleoplasm] (R-MMU-2176420) Nedd4l [cytosol] (R-MMU-976003)	0.524	2
UniProt:P01111 NRAS	25	NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS Q60E [plasma membrane] (R-HSA-9656589) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) NRAS [plasma membrane] (R-HSA-62725) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) proNRAS [cytosol] (R-HSA-9647758)	0.499	2
UniProt:P15056 BRAF	68	p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF [cytosol] (R-HSA-167224) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.499	3