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UIMC1 [nucleoplasm]
Stable Identifier
R-MMU-5682574
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q5U5Q9
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G2/M Checkpoints (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
CHEK2 is recruited to DNA DSBs (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
Phosphorylation and activation of CHEK2 by ATM (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
CHEK2 is recruited to DNA DSBs (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
CHEK2 phosphorylates BRCA1 (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-5S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
Formation of BRCA1-A complex at DNA DSBs (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Mus musculus)
BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
Phosphorylation and activation of CHEK2 by ATM (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Mus musculus)
BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
UIMC1 and FAM175A bind DNA DSBs (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
PIAS4 SUMOylates MDC1 (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-5S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-5S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
RNF4 ubiquitinates MDC1 (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-5S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
Nonhomologous End-Joining (NHEJ) (Mus musculus)
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Mus musculus)
p-5S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Metalloprotease DUBs (Mus musculus)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)
BRCA1-A Complex:Histone H2A [nucleoplasm] (Mus musculus)
BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm] (Mus musculus)
BRCA1-A Complex [nucleoplasm] (Mus musculus)
UIMC1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q5U5Q9
Reference Genes
BioGPS Gene:20184
ENSEMBL:ENSMUSG00000025878
KEGG Gene (Mus musculus):20184
Monarch:20184
NCBI Gene:20184
UCSC:Q5U5Q9
Reference Transcript
RefSeq:XM_006517166.2
RefSeq:NM_011307.2
RefSeq:NM_001293660.1
Participates
as an output of
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)
RNF4 ubiquitinates MDC1 (Mus musculus)
as an input of
UIMC1 and FAM175A bind DNA DSBs (Mus musculus)
as a component of
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] (Mus musculus)
BRCA1-A Complex [nucleoplasm] (Mus musculus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
p-5S,2T-BRCA1-A Complex [nucleoplasm] (Mus musculus)
Inferred From
UIMC1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001280589.1
,
NP_035437.1
,
XP_006517229.1
PRO
Q5U5Q9
MGI
103185
PDB
3A1Q
,
6GVW
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62991 UBIQ
0.558
2
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