Reactome | Hdac2 [nucleoplasm]

Hdac2 [nucleoplasm]

Stable Identifier

R-MMU-573366

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Histone deacetylase 2, HDAC2_MOUSE, Hdac2

Locations in the PathwayBrowser

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Chromatin organization (Mus musculus)

- Chromatin modifying enzymes (Mus musculus)
  - HDACs deacetylate histones (Mus musculus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        BHC complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        CoREST complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        Sin3A complex [nucleoplasm] (Mus musculus)
        
        Sin3a core complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        BHC complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        CoREST complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        Sin3A complex [nucleoplasm] (Mus musculus)
        
        Sin3a core complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
    - HDAC1:2-containing complex deacetylate histones (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        BHC complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        CoREST complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        Sin3A complex [nucleoplasm] (Mus musculus)
        
        Sin3a core complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        BHC complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        CoREST complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        Sin3A complex [nucleoplasm] (Mus musculus)
        
        Sin3a core complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase I Transcription (Mus musculus)
  - RNA Polymerase I Promoter Clearance (Mus musculus)
    - RNA Polymerase I Transcription Initiation (Mus musculus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Notch-HLH transcription pathway (Mus musculus)
      - Formation of CSL NCOR corepressor complex (Mus musculus)
        
        HDAC [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        RBPJ:NCOR corepressor complex [nucleoplasm] (Mus musculus)
        
        HDAC [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
    - Transcriptional Regulation by MECP2 (Mus musculus)
      - Regulation of MECP2 expression and activity (Mus musculus)
        
        MECP2 binds the SIN3A co-repressor complex (Mus musculus)
        
        MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Mus musculus)
        
        MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Mus musculus)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        MECP2:SIN3A:HDAC2 [nucleoplasm] (Mus musculus)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Mus musculus)
        
        Hdac2 homodimer [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Mus musculus)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Mus musculus)
        
        Hdac2 homodimer [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Acetylation (Mus musculus)
        
        MTA2-NuRD complex deacetylates TP53 (Mus musculus)
        
        MTA2-NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)

Hemostasis (Mus musculus)

- Factors involved in megakaryocyte development and platelet production (Mus musculus)
  - REST recruits the BHC complex (Mus musculus)
    - BHC complex [nucleoplasm] (Mus musculus)
      - Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
    - BHC complex:REST:REST DNA binding sites [nucleoplasm] (Mus musculus)
      - BHC complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - SUMOylation (Mus musculus)
    - SUMO E3 ligases SUMOylate target proteins (Mus musculus)
      - SUMOylation of chromatin organization proteins (Mus musculus)
        
        SUMOylation of HDAC2 with SUMO1 (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        SALL4 recruits NuRD to PTEN gene (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Hdac1:Hdac2 [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by ALK (Mus musculus)
    - STAT3 nuclear events downstream of ALK signaling (Mus musculus)
      - HDACs deacetylate p-STAT3 dimers (Mus musculus)
        
        Histone deacetylase [nucleoplasm] (Mus musculus)
        
        Hdac2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P70288 Hdac2

Gene Names

Hdac2, Yy1bp

Chain

chain:1-488

Reference Genes

BioGPS Gene:15182 Hdac2

KEGG Gene (Mus musculus):15182 Hdac2

Monarch:15182 Hdac2

NCBI Gene:15182 Hdac2

UCSC:P70288 Hdac2

Reference Transcript

RefSeq:NM_008229.2 Hdac2

Participates

as an input of

as a component of

as a member of

Histone deacetylase [nucleoplasm] (Mus musculus)

as a candidate of

HDAC [nucleoplasm] (Mus musculus)

Other forms of this molecule

monoSUMO1-K462-HDAC2 [nucleoplasm]

Inferred From

HDAC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_032255.2

IntEnz

3.5.1.98

PRO

P70288

MGI

1097691

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60520 Sin3a	3	Sin3a [nucleoplasm] (R-MMU-4086071) Sin3a [nucleoplasm] (R-MMU-573326) Sin3a [nucleoplasm] (R-MMU-351657)	0.784	7
UniProt:Q9R190 Mta2	1	Mta2 [nucleoplasm] (R-MMU-5096453)	0.708	7
UniProt:O09106 Hdac1	2	Hdac1 [nucleoplasm] (R-MMU-4616030) Hdac1 [nucleoplasm] (R-MMU-573340)	0.643	5
UniProt:Q6ZQ88	1	KDM1A [nucleoplasm] (R-MMU-996769)	0.623	4
UniProt:Q62233 SIX3			0.544	2
UniProt:E9QAG8	17	Znf431 [nucleoplasm] (R-MMU-9843457-20) Znf431 [nucleoplasm] (R-MMU-9843461-20) Znf431 [nucleoplasm] (R-MMU-9843524-20) Znf431 [nucleoplasm] (R-MMU-2586613-20) Znf431 [nucleoplasm] (R-MMU-1027421-20) Znf431 [nucleoplasm] (R-MMU-1247531-20) Znf431 [nucleoplasm] (R-MMU-1247542-20) Znf431 [nucleoplasm] (R-MMU-2127573-20) Znf431 [nucleoplasm] (R-MMU-2127569-20) Znf431 [nucleoplasm] (R-MMU-3323094-20) Znf431 [nucleoplasm] (R-MMU-2127597-20) Znf431 [nucleoplasm] (R-MMU-975011-20) Znf431 [nucleoplasm] (R-MMU-975012-20) Znf431 [nucleoplasm] (R-MMU-1973899-20) Znf431 [nucleoplasm] (R-MMU-1247871-20) Znf431 [nucleoplasm] (R-MMU-1247857-20) Znf431 [nucleoplasm] (R-MMU-2454142-20)	0.524	3
UniProt:Q3TKT4 Smarca4	2	SMARCA4 [nucleoplasm] (R-MMU-201686) Smarca4 [nucleoplasm] (R-MMU-9727480)	0.499	4
UniProt:Q8C796 RCOR2			0.499	2
UniProt:P11103	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-MMU-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-MMU-4551686) PAR-PARP1 [nucleoplasm] (R-MMU-5651713) PARP1 [nucleoplasm] (R-MMU-201568)	0.499	3
UniProt:O35846 O35846			0.463	3
UniProt:O54864	1	SUV39H1 [nucleoplasm] (R-MMU-427517)	0.462	2
UniProt:Q60I23 Q60I23			0.462	2
UniProt:Q6AXH7 Q6AXH7			0.462	2
UniProt:P48432 Sox2	2	Sox2 [nucleoplasm] (R-MMU-3246072) Sox2 [nucleoplasm] (R-MMU-452271)	0.462	2