Transcription of intergenic spacer of the rRNA gene

Stable Identifier
R-MMU-573384
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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Medium
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 | PPTX  | SBGN
Transcription of intergenic spacer of the rRNA gene
Intergenic spacer regions (IGS) located between rRNA transcription units contain upstream promoters and are transcribed by RNA Polymerase I. The IGS transcripts originate approximately 2 Kb upstream of the start of rRNA transcription and proceed though the main promoter of the rRNA gene.
Literature References
PubMed ID Title Journal Year
20010804 Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans

Schmitz, KM, Sandoval, J, Santoro, R, Grummt, I

EMBO Rep. 2010
16678107 Intergenic transcripts regulate the epigenetic state of rRNA genes

Mayer, C, Santoro, R, Grummt, I, Li, J, Schmitz, KM

Mol Cell 2006
Participants
Input
Output
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase I Holoenzyme [nucleoplasm]

Physical Entity
RNA Polymerase I Holoenzyme [nucleoplasm] (Mus musculus)
Activity
DNA-directed 5'-3' RNA polymerase activity (GO:0003899)
Orthologous Events
Transcription of intergenic spacer of the rRNA gene (Homo sapiens)
Authored
May, B  (2010-04-06)
Reviewed
Shiao, YH  (2014-02-18)
Created
May, B  (2010-04-10)
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