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MAPK3 [cytosol]
Stable Identifier
R-MMU-59284
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q63844
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
L1CAM interactions (Mus musculus)
Signal transduction by L1 (Mus musculus)
MAP2K1 phosphorylates MAPK3 (Mus musculus)
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Thrombin signalling through proteinase activated receptors (PARs) (Mus musculus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Mus musculus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
F2R:ARRB1 binds MAPKs, SRC-1 (Mus musculus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
F2R:ARRB2 binds MAPKs, SRC-1 (Mus musculus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
SRC-1 bound to ARRB2 is not activated (Mus musculus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Mus musculus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Growth hormone receptor signaling (Mus musculus)
Lyn activates ERK (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
ISG15 antiviral mechanism (Mus musculus)
ISGylation of host proteins (Mus musculus)
ISG15 targets [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
ISGylated host proteins [cytosol] (Mus musculus)
ISG15 targets [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)
ISG15 targets [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
ISGylated host proteins [cytosol] (Mus musculus)
ISG15 targets [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Interferon gamma signaling (Mus musculus)
IFNG signaling activates MAPKs (Mus musculus)
JAK1-activated RAF1 phosphorylates MAPKs (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
MAPK monomers and dimers [cytosol] (Mus musculus)
MAPK3 dimer [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAPK3 (ERK1) activation (Mus musculus)
MAP2K1 binds MAPK3 (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAP2K1 phosphorylates MAPK3 (Mus musculus)
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
MAPK monomers and dimers [cytosol] (Mus musculus)
MAPK3 dimer [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
Signal attenuation (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)
MAPK3,(MAPK1) [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)
MAPK3,(MAPK1) [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
Frs2-mediated activation (Mus musculus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q63844 Mapk3
Gene Names
Mapk3, Erk1, Prkm3
Chain
initiator methionine:, chain:2-380
Reference Genes
BioGPS Gene:26417 Mapk3
KEGG:mmu:26417 Mapk3
Monarch:26417 Mapk3
NCBI Gene:26417 Mapk3
UCSC:Q63844 Mapk3
Reference Transcript
RefSeq:NM_011952.2 Mapk3
Other Identifiers
101834_at
10557459
1427060_at
17483084
26417
4307472
4393458
4526185
4647296
4660403
4672181
4818171
5118307
5218307
5244382
5306004
5413360
5535084
5588282
A_52_P243249
A_55_P2121662
GE42900
GO:0000165
GO:0001784
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006351
GO:0006355
GO:0006468
GO:0006796
GO:0006914
GO:0006915
GO:0006974
GO:0007165
GO:0008286
GO:0009636
GO:0009887
GO:0010759
GO:0012501
GO:0014032
GO:0014044
GO:0016020
GO:0016192
GO:0016740
GO:0019233
GO:0019902
GO:0022414
GO:0030154
GO:0030278
GO:0030509
GO:0030641
GO:0030878
GO:0031143
GO:0031410
GO:0031663
GO:0032206
GO:0032496
GO:0032872
GO:0032991
GO:0034198
GO:0034614
GO:0035556
GO:0038133
GO:0042473
GO:0042552
GO:0042770
GO:0042802
GO:0043226
GO:0043330
GO:0045727
GO:0045944
GO:0046697
GO:0048009
GO:0048538
GO:0048856
GO:0050804
GO:0050877
GO:0051090
GO:0051216
GO:0051403
GO:0051493
GO:0060020
GO:0060324
GO:0060425
GO:0060440
GO:0061308
GO:0065003
GO:0070161
GO:0070371
GO:0070374
GO:0070498
GO:0070849
GO:0071260
GO:0071276
GO:0071356
GO:0072584
GO:0090170
GO:0097110
GO:0098792
GO:0098978
GO:0106310
GO:0120041
GO:0140096
GO:0140297
GO:0141124
GO:1904262
GO:1904417
GO:2000641
GO:2000657
ILMN_1218551
ILMN_2661579
ILMN_2715744
Msa.2276.0_s_at
mMC019926
mMR001455
Participates
as a member of
ISG15 targets [cytosol] (Mus musculus)
MAPK3,(MAPK1) [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
as a component of
MAPK3 dimer [cytosol] (Mus musculus)
p-2S-MAP2K1:MAPK3 [cytosol] (Mus musculus)
as an input of
MAP2K1 binds MAPK3 (Mus musculus)
Other forms of this molecule
phospho-p-Y204-MAPK3-3 [cytosol]
phospho-p-T202-MAPK3 [cytosol]
p-T203,Y205-Mapk3 [nucleoplasm]
MAPK3 [nucleoplasm]
phospho-p-T202,Y204-MAPK3 [cytosol]
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
Inferred From
MAPK3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_036082.1
ENSEMBL
ENSMUST00000057669
,
ENSMUSP00000051619
,
ENSMUSG00000063065
IntEnz
2.7.11.24
PRO
Q63844
MGI
1346859
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60793 Klf4
2
Klf4 [nucleoplasm]
(R-MMU-977397)
Klf4 [nucleoplasm]
(R-MMU-434463)
0.508
3
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
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