Reactome | Ndufa8 [mitochondrial inner membrane]

Ndufa8 [mitochondrial inner membrane]

Stable Identifier

R-MMU-60627

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

mitochondrial inner membrane

Synonyms

NDUFA8, Q9DCJ5

Locations in the PathwayBrowser

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Metabolism (Mus musculus)

- Aerobic respiration and respiratory electron transport (Mus musculus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Mus musculus)
    - Respiratory electron transport (Mus musculus)
      - Complex I biogenesis (Mus musculus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa8 [mitochondrial inner membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9DCJ5

Gene Names

Ndufa8

Reference Genes

BioGPS Gene:68375 Ndufa8

ENSEMBL:ENSMUSG00000026895

ENSEMBL:ENSMUSG00000026895.8 Ndufa8

KEGG Gene (Mus musculus):68375 Ndufa8

Monarch:68375 Ndufa8

NCBI Gene:68375 Ndufa8

UCSC:Q9DCJ5 Ndufa8

Reference Transcript

RefSeq:NM_026703.2 Ndufa8

Other Identifiers

10482089

1423692_at

17384525

4662693

4666977

4817909

4893612

4969075

5218429

5218430

5359832

68375

93531_at

A_51_P475501

A_51_P475502

GE122711

GO:0005739

GO:0005743

GO:0005747

GO:0005758

GO:0006091

GO:0006120

GO:0007005

GO:0009060

GO:0016020

GO:0032981

GO:0042776

GO:0043226

GO:0044877

GO:0055086

GO:0065003

GO:0070469

GO:1901135

ILMN_2682019

ILMN_2880067

mMC009639

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Mus musculus)

Inferred From

NDUFA8 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_080979.1

Ensembl

ENSMUSP00000065352, ENSMUSG00000026895, ENSMUST00000070112

PRO

Q9DCJ5

MGI

1915625

PDB

6G2J, 6ZTQ, 8OLT, 7PSA, 6ZR2, 6G72, 8OM1, 7AK5, 7B93, 7AK6

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