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What is Reactome ?
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TRADD [cytosol]
Stable Identifier
R-MMU-66376
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q3U0V2
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Dimerization of procaspase-8 (Mus musculus)
TNF-mediated dimerization of procaspase-8 (Mus musculus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
CASP8 activity is inhibited (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
FLIP(S) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
CLIP3 and CYLD bind TNF signaling complex (Mus musculus)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
K63polyUb-RIPK1 is deubiquitinated (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
MAPKAPK2 phosphorylates RIPK1 at S320 (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
OPTN recruits CYLD to the TNFR1 complex (Mus musculus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Mus musculus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Mus musculus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
ULK1 phosphorylates RIPK1 at S357 (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNFR1-induced proapoptotic signaling (Mus musculus)
TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Mus musculus)
TRADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
TRADD [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q3U0V2
Reference Genes
BioGPS Gene:71609
ENSEMBL:ENSMUSG00000031887
ENSEMBL:ENSMUSG00000031887.14
KEGG Gene (Mus musculus):71609
Monarch:71609
NCBI Gene:71609
UCSC:Q3U0V2
Reference Transcript
RefSeq:NM_001033161.2
Other Identifiers
10581181
136534_at
1429117_at
1452622_a_at
160689_r_at
17512342
4419533
4452775
4538411
4654079
4675439
5103297
5192424
5387203
5442073
5580064
5594001
71609
A_51_P288505
GE40228
GO:0002947
GO:0005068
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005856
GO:0005886
GO:0006915
GO:0006954
GO:0007165
GO:0007169
GO:0007249
GO:0012501
GO:0019900
GO:0023052
GO:0030335
GO:0032728
GO:0032991
GO:0033209
GO:0042802
GO:0042981
GO:0043123
GO:0043226
GO:0043235
GO:0044877
GO:0048856
GO:0048870
GO:0050729
GO:0051798
GO:0060090
GO:0070513
GO:0071356
GO:0097191
GO:1901224
ILMN_1233313
ILMN_2505100
mMC013666
Participates
as an input of
TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)
as a component of
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Mus musculus)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Inferred From
TRADD [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001028333.1
Ensembl
ENSMUSP00000034359
,
ENSMUST00000034359
,
ENSMUSG00000031887
PRO
Q3U0V2
MGI
109200
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9QUK6
2
Tlr4 [endosome membrane]
(R-MMU-2201285)
Tlr4 [plasma membrane]
(R-MMU-166045)
0.499
3
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.499
2
UniProt:Q60855
14
K48polyUb-RIPK1 [cytosol]
(R-MMU-6783308)
PolyUb-RIPK1 [cytosol]
(R-MMU-6783197)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-MMU-9796639)
RIPK1 [cytosol]
(R-MMU-168651)
K63polyUb-RIPK1 [cytosol]
(R-MMU-937021)
phospho-p-S166-RIPK1 [cytosol]
(R-MMU-5218872)
phospho-p-S357-RIPK1 [cytosol]
(R-MMU-9819116)
phospho-p-S320-RIPK1 [cytosol]
(R-MMU-9815498)
phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-MMU-9817377)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-MMU-9818391)
RIPK1(325-671) [cytosol]
(R-MMU-5212671)
RIPK1(1-324) [cytosol]
(R-MMU-5212664)
K63,M1polyUb-RIPK1 [cytosol]
(R-MMU-9793681)
phospho-K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-MMU-9818793)
0.499
2
UniProt:Q9QWL7
1
Krt17 [cytosol]
(R-MMU-201583)
0.488
2
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