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XPA [nucleoplasm]
Stable Identifier
R-MMU-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q64267
Locations in the PathwayBrowser
Expand all
DNA Repair (Mus musculus)
Nucleotide Excision Repair (Mus musculus)
Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
Dual Incision in GG-NER (Mus musculus)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Formation of Incision Complex in GG-NER (Mus musculus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
CHD1L is recruited to GG-NER site (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Formation of the pre-incision complex in GG-NER (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
RNF111 ubiquitinates SUMOylated XPC (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Recruitment of XPA and release of CAK (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
SUMOylation of XPC (Mus musculus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
Dual incision in TC-NER (Mus musculus)
3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
ERCC5 and RPA bind TC-NER site (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Formation of TC-NER Pre-Incision Complex (Mus musculus)
Assembly of the pre-incision complex in TC-NER (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
XPA [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q64267
Reference Genes
BioGPS Gene:22590
ENSEMBL:ENSMUSG00000028329
KEGG:mmu:22590
Monarch:22590
NCBI Gene:22590
UCSC:Q64267
Reference Transcript
RefSeq:NM_011728.2
Other Identifiers
10512739
1460725_at
17424998
22590
4358793
4379744
4432069
4553351
4688748
4907111
4994663
5040227
5043475
5149371
5153141
5393544
5518947
5579171
5579572
92384_at
A_52_P83233
A_55_P1967867
A_66_P100657
GE36454
GO:0000110
GO:0000715
GO:0003677
GO:0003684
GO:0005634
GO:0005654
GO:0005662
GO:0006281
GO:0006284
GO:0006289
GO:0006355
GO:0006979
GO:0008630
GO:0009411
GO:0009636
GO:0009650
GO:0010506
GO:0019904
GO:0034504
GO:0035264
GO:0042803
GO:0043226
GO:0045171
GO:0046872
GO:0060261
GO:0070914
GO:1901255
GO:1990837
ILMN_1243334
ILMN_1256088
ILMN_2968515
mMC010166
mMR031193
x74351_s_at
Participates
as an output of
3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)
as a component of
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
as an input of
Assembly of the pre-incision complex in TC-NER (Mus musculus)
Recruitment of XPA and release of CAK (Mus musculus)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_035858.2
ENSEMBL
ENSMUST00000030013
,
ENSMUST00000142380
,
ENSMUSP00000121850
,
ENSMUSP00000030013
PRO
Q64267
MGI
99135
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