Reactome | Mdm4 [nucleoplasm]

Mdm4 [nucleoplasm]

Stable Identifier

R-MMU-6782502

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

PolyUb-MDM4, O35618

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Deubiquitination (Mus musculus)
    - Ub-specific processing proteases (Mus musculus)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)
        
        USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)
        
        PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)
        
        Mdm4 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O35618

Gene Names

Mdm4

Reference Genes

BioGPS Gene:17248 Mdm4

ENSEMBL:ENSMUSG00000054387

ENSEMBL:ENSMUSG00000054387 Mdm4

KEGG Gene (Mus musculus):17248 Mdm4

Monarch:17248 Mdm4

NCBI Gene:17248 Mdm4

UCSC:O35618 Mdm4

Reference Transcript

Other Identifiers

10357773

108903_at

1419558_at

1460542_s_at

163238_f_at

17226953

17248

4323807

4329064

4357665

4363801

4403903

4422956

4470821

4642719

4677126

4713249

4765576

4767954

4941918

5080653

5083260

5109906

5127075

5133495

5158739

5225740

5277480

5293297

5321623

5346209

5423162

5425125

5488268

5527584

5605811

93338_at

93339_at

A_30_P01026248

A_30_P01028787

A_30_P01028801

A_30_P01030039

A_30_P01032509

A_30_P01032561

A_30_P01032960

A_51_P176954

A_51_P258566

A_52_P174937

A_52_P485905

A_52_P596201

A_55_P2081388

GE1395710

GE34006

GO:0000122

GO:0002027

GO:0002039

GO:0003013

GO:0003170

GO:0003181

GO:0003203

GO:0003281

GO:0003283

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006357

GO:0008284

GO:0012501

GO:0017053

GO:0019899

GO:0023052

GO:0030163

GO:0030330

GO:0032991

GO:0042177

GO:0043066

GO:0043226

GO:0045892

GO:0046872

GO:0048856

GO:0051726

GO:0065003

GO:0065008

GO:1902254

ILMN_1227293

ILMN_1257423

ILMN_2644167

ILMN_2877527

mMC014315

mMR027595

mMR027622

Participates

as a member of

PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)

Other forms of this molecule

phospho-Mdm4 [nucleoplasm]

Mdm4 [nucleoplasm]

Inferred From

PolyUb-MDM4 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001289731.1, NP_032601.2, NP_001289733.1, NP_001289732.1, NP_001289730.1

Ensembl

ENSMUSG00000054387, ENSMUST00000188090, ENSMUSP00000140609, ENSMUSP00000070411, ENSMUST00000067429

PRO

O35618

MGI

107934

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.641	4
UniProt:P02340	20	TP53 [cytosol] (R-MMU-8869337) PolyUb-TP53 [nucleoplasm] (R-MMU-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-MMU-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-MMU-3222242) phospho-Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-MMU-6805656) phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-MMU-6805631) phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-MMU-5628868) phospho-p-S15,S392-TP53 [nucleoplasm] (R-MMU-3222015) phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-MMU-6804446) phospho-p-T55-TP53 [nucleoplasm] (R-MMU-6805400) phospho-p-S315-TP53 [nucleoplasm] (R-MMU-6805106) phospho-p-S15,S20,S46-TP53 [nucleoplasm] (R-MMU-6798369) phospho-p-S15,S33,S46-TP53 [nucleoplasm] (R-MMU-6805268) phospho-p-S15,S20,S392-TP53 [nucleoplasm] (R-MMU-6805053) phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-MMU-6805133) phospho-Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-MMU-6805719) phospho-Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-MMU-3222124) phospho-p-S15,S20-TP53 [nucleoplasm] (R-MMU-69683) phospho-p-S15-TP53 [nucleoplasm] (R-MMU-69507) TP53 [nucleoplasm] (R-MMU-69488)	0.589	2
UniProt:P23804 Mdm2	12	phospho-Mdm2 [nucleoplasm] (R-MMU-6793669) phospho-Mdm2 [cytosol] (R-MMU-198638) Mdm2 [cytosol] (R-MMU-198644) Mdm2 [nucleoplasm] (R-MMU-69486) phospho-Mdm2 [nucleoplasm] (R-MMU-6795669) phospho-Mdm2 [nucleoplasm] (R-MMU-6804954) phospho-Mdm2 [nucleoplasm] (R-MMU-6792862) Mdm2 [endocytic vesicle membrane] (R-MMU-416849) Mdm2 [plasma membrane] (R-MMU-416843) Mdm2 [cytosol] (R-MMU-9769903) Mdm2 [nucleoplasm] (R-MMU-3000408) Mdm2 [nucleoplasm] (R-MMU-6782472)	0.564	2

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