Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PolyUb-TP53 [nucleoplasm]
Stable Identifier
R-MMU-6782509
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
P02340
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)
USP10,USP24,USP42:PolyUb-TP53 [nucleoplasm] (Mus musculus)
PolyUb-TP53 [nucleoplasm] (Mus musculus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)
PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)
PolyUb-TP53 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P02340 Tp53
Gene Names
Tp53, P53, Trp53
Chain
chain:1-390
Reference Genes
BioGPS Gene:22059 Tp53
CTD Gene:22059 Tp53
ENSEMBL:ENSMUSG00000059552.14 Tp53
KEGG Gene (Mus musculus):22059 Tp53
Monarch:22059 Tp53
NCBI Gene:22059 Tp53
UCSC:P02340 Tp53
Reference Transcript
RefSeq:XM_006533157.3 Tp53
RefSeq:NM_011640.3 Tp53
RefSeq:NM_001127233.1 Tp53
Other Identifiers
10377550
104154_at
104275_g_at
1426538_a_at
1427739_a_at
17251659
22059
4380436
4386905
4394488
4640586
4658090
4677848
4682241
4848244
4924399
4926754
4964608
5198486
5342616
5467410
5528718
5613651
A_52_P491849
A_55_P1968068
GE36238
GO:0000122
GO:0000278
GO:0000423
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001046
GO:0001094
GO:0001221
GO:0001227
GO:0001228
GO:0001701
GO:0001756
GO:0001836
GO:0002020
GO:0002039
GO:0002244
GO:0002309
GO:0002326
GO:0002360
GO:0002376
GO:0002687
GO:0002931
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0003730
GO:0005507
GO:0005515
GO:0005634
GO:0005654
GO:0005657
GO:0005667
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005783
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005975
GO:0006091
GO:0006260
GO:0006281
GO:0006289
GO:0006302
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0006974
GO:0006977
GO:0006978
GO:0006979
GO:0006983
GO:0007005
GO:0007049
GO:0007179
GO:0007265
GO:0007283
GO:0007346
GO:0007369
GO:0007405
GO:0007406
GO:0007417
GO:0007507
GO:0007623
GO:0008104
GO:0008156
GO:0008283
GO:0008285
GO:0008340
GO:0009299
GO:0009303
GO:0009410
GO:0009411
GO:0009651
GO:0009792
GO:0010035
GO:0010165
GO:0010332
GO:0010628
GO:0010629
GO:0010659
GO:0010666
GO:0012501
GO:0014009
GO:0016032
GO:0016071
GO:0016363
GO:0016604
GO:0016605
GO:0017053
GO:0019661
GO:0019899
GO:0021549
GO:0022414
GO:0023052
GO:0030154
GO:0030308
GO:0030330
GO:0030512
GO:0030971
GO:0031047
GO:0031571
GO:0031625
GO:0032200
GO:0032211
GO:0032991
GO:0033077
GO:0033209
GO:0034103
GO:0034614
GO:0034644
GO:0035033
GO:0035264
GO:0035794
GO:0035861
GO:0036211
GO:0036310
GO:0042127
GO:0042149
GO:0042771
GO:0042802
GO:0042826
GO:0042981
GO:0043065
GO:0043066
GO:0043073
GO:0043153
GO:0043226
GO:0043504
GO:0043516
GO:0043523
GO:0043525
GO:0043565
GO:0043621
GO:0044325
GO:0045787
GO:0045815
GO:0045861
GO:0045892
GO:0045893
GO:0045899
GO:0045930
GO:0045944
GO:0046677
GO:0046872
GO:0046982
GO:0048144
GO:0048147
GO:0048511
GO:0048512
GO:0048539
GO:0048568
GO:0048662
GO:0048856
GO:0048870
GO:0050731
GO:0050821
GO:0051087
GO:0051262
GO:0051276
GO:0051402
GO:0051453
GO:0051721
GO:0051726
GO:0055086
GO:0060218
GO:0060253
GO:0060333
GO:0060411
GO:0061024
GO:0061629
GO:0062100
GO:0065003
GO:0070059
GO:0070242
GO:0070243
GO:0070245
GO:0070266
GO:0071456
GO:0071466
GO:0071479
GO:0071480
GO:0071494
GO:0071889
GO:0072089
GO:0072331
GO:0072332
GO:0072593
GO:0072717
GO:0090200
GO:0090398
GO:0090399
GO:0090403
GO:0090575
GO:0097190
GO:0097252
GO:0097371
GO:0097718
GO:0098542
GO:0098772
GO:0140110
GO:0140296
GO:0140657
GO:0140677
GO:1900119
GO:1901135
GO:1901525
GO:1902108
GO:1902253
GO:1902749
GO:1902895
GO:1903451
GO:1903799
GO:1904024
GO:1905856
GO:1990144
GO:1990841
GO:2000269
GO:2000279
GO:2000378
GO:2000379
GO:2000647
GO:2000772
GO:2000774
GO:2001233
GO:2001244
ILMN_2466845
k01700-2_s_at
mMC013659
Participates
as a component of
USP10,USP24,USP42:PolyUb-TP53 [nucleoplasm] (Mus musculus)
as a member of
PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)
Other forms of this molecule
TP53 [cytosol]
polySUMO2,3-K386-TP53 [nucleoplasm]
p- S18-Tp53 [nucleoplasm]
phospho-p-S392-TP53 [nucleoplasm]
Me2K-370,382-TP53 [nucleoplasm]
Me2-K373-TP53 [nucleoplasm]
phospho-p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
phospho-MeK-370,p-S15,S20-TP53 [nucleoplasm]
phospho-Me-K382,p-S15,S20-TP53 [nucleoplasm]
phospho-Me1-K372,p-S15,S20-TP53 [nucleoplasm]
phospho-Ac-K120,p-S15,S20-TP53 [nucleoplasm]
phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm]
phospho-p-S15,S392-TP53 [nucleoplasm]
phospho-p-S315-TP53 [nucleoplasm]
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
phospho-p-S15,S20-TP53 [nucleoplasm]
phospho-p-S15-TP53 [nucleoplasm]
TP53 [nucleoplasm]
PolyUb-TP53 [cytosol]
PolyUb-TP53 [nucleoplasm]
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
phospho-p-S37-TP53 [nucleoplasm]
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
phospho-p-T55-TP53 [nucleoplasm]
phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm]
phospho-p-S15,S20,S46-TP53 [nucleoplasm]
Inferred From
PolyUb-TP53 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [cytosol]) at unknown position
Modification
PolyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_006533220.1
,
NP_035770.2
,
NP_001120705.1
Ensembl
ENSMUSG00000059552
,
ENSMUSP00000104298
,
ENSMUST00000108658
PRO
P02340
MGI
98834
PDB
2IOM
,
2GEQ
,
1HU8
,
2P52
,
2IOI
,
3EXJ
,
2IOO
,
3EXL
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03070 LT
0.968
22
UniProt:P23804 Mdm2
12
phospho-Mdm2 [nucleoplasm]
(R-MMU-6793669)
phospho-Mdm2 [cytosol]
(R-MMU-198638)
Mdm2 [cytosol]
(R-MMU-198644)
Mdm2 [nucleoplasm]
(R-MMU-69486)
phospho-Mdm2 [nucleoplasm]
(R-MMU-6792862)
phospho-Mdm2 [nucleoplasm]
(R-MMU-6795669)
phospho-Mdm2 [nucleoplasm]
(R-MMU-6804954)
Mdm2 [endocytic vesicle membrane]
(R-MMU-416849)
Mdm2 [plasma membrane]
(R-MMU-416843)
Mdm2 [cytosol]
(R-MMU-9769903)
Mdm2 [nucleoplasm]
(R-MMU-3000408)
Mdm2 [nucleoplasm]
(R-MMU-6782472)
0.918
9
ChEBI:15422 ATP
0.73
3
UniProt:P62991 UBIQ
0.702
4
UniProt:B2RWS6 Ep300
4
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-MMU-3899306)
phospho-p-S,T-EP300 [nucleoplasm]
(R-MMU-8878072)
Ep300 [nucleoplasm]
(R-MMU-556805)
EP300 [nucleoplasm]
(R-MMU-381325)
0.702
3
UniProt:O35618
5
Mdm4 [nucleoplasm]
(R-MMU-6782502)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349461)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349441)
phospho-Mdm4 [nucleoplasm]
(R-MMU-6804938)
Mdm4 [nucleoplasm]
(R-MMU-349430)
0.589
2
UniProt:P97302
5
phospho-Bach1 [cytosol]
(R-MMU-9762206)
phospho-Bach1 [nucleoplasm]
(R-MMU-9762202)
Bach1 [nucleoplasm]
(R-MMU-9708486)
Bach1 [cytosol]
(R-MMU-9708429)
Bach1 [nucleoplasm]
(R-MMU-9707688)
0.558
4
UniProt:P63158
5
HMGB1 [secretory granule lumen]
(R-MMU-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-MMU-6803291)
HMGB1 [extracellular region]
(R-MMU-879382)
HMGB1 [nucleoplasm]
(R-MMU-266221)
HC23,45-HMGB1 [extracellular region]
(R-MMU-6797422)
0.558
2
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.553
2
UniProt:O08586
13
Pten [cytosol]
(R-MMU-8874327)
Pten [nucleoplasm]
(R-MMU-6782515)
phospho-Pten [cytosol]
(R-MMU-8847980)
Pten [cytosol]
(R-MMU-199420)
Pten [nucleoplasm]
(R-MMU-6807273)
Pten [nucleoplasm]
(R-MMU-6807264)
Pten [cytosol]
(R-MMU-6807247)
Pten [cytosol]
(R-MMU-8948777)
Pten [cytosol]
(R-MMU-6807280)
Pten [cytosol]
(R-MMU-8851009)
phospho-Pten [cytosol]
(R-MMU-8850936)
phospho-Pten [cytosol]
(R-MMU-8948798)
phospho-Pten [cytosol]
(R-MMU-8948841)
0.537
4
UniProt:Q61466 Smarcd1
1
Smarcd1 [nucleoplasm]
(R-MMU-9727494)
0.508
4
UniProt:Q64127 TIF1A
0.499
2
UniProt:Q07817-1 BCL2L1
0.499
3
UniProt:Q60979 Q60979
0.463
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text