Reactome | Keap1 [cytosol]

Keap1 [cytosol]

Stable Identifier

R-MMU-6782766

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Ub-KEAP1, Q9Z2X8

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Deubiquitination (Mus musculus)
    - Ub-specific processing proteases (Mus musculus)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9Z2X8

Gene Names

Keap1

Reference Genes

BioGPS Gene:50868 Keap1

ENSEMBL:ENSMUSG00000003308

KEGG:mmu:50868 Keap1

Monarch:50868 Keap1

NCBI Gene:50868 Keap1

UCSC:Q9Z2X8 Keap1

Reference Transcript

Other Identifiers

10591482

1450746_at

1450747_at

17524659

4308634

4450046

4483518

4547708

4705568

4772799

4919759

5045304

50868

5238700

5338496

5430939

5454466

5552467

A_51_P438666

GE36980

GO:0000122

GO:0001701

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005884

GO:0005912

GO:0005925

GO:0006355

GO:0006511

GO:0010506

GO:0010629

GO:0016234

GO:0016567

GO:0030496

GO:0031463

GO:0032991

GO:0034451

GO:0034599

GO:0042802

GO:0043226

GO:0045604

GO:0048856

GO:0060090

GO:0061629

GO:0071322

GO:0071353

GO:0097718

GO:0098772

GO:0140416

GO:1902883

GO:1990756

ILMN_1258406

ILMN_2442976

ILMN_2621346

ILMN_2707771

ILMN_2993267

mMC006958

Participates

as a member of

Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)

Other forms of this molecule

Keap1 [cytosol]

Inferred From

Ub-KEAP1 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position

Modification

polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001103777.1, NP_001103775.1, NP_001103776.1, NP_057888.1

ENSEMBL

ENSMUSP00000141807, ENSMUSP00000062467, ENSMUST00000049567, ENSMUST00000193982, ENSMUSP00000131029, ENSMUST00000194542, ENSMUSP00000141840, ENSMUST00000164812

PRO

Q9Z2X8

MGI

1858732

GlyGen

Q9Z2X8

PDB

7ECA, 6QMC, 5FZJ, 1X2J, 6QMJ, 7OF8, 5FZN, 6QME, 6QMK, 5FNR, 7YEN, 5FNQ, 5FNT, 5CGJ, 6ZF2, 2DYH, 6ZEZ, 1X2R, 7OFC, 8Q1Q, 6ZF4, 7P5E, 6ZEY, 6ZF6, 6ZF1, 6ZEW, 7P5I, 8IN0, 8A46, 4ZY3, 7P58, 5FNU, 7OFF, 7OFA, 6QMD, 7OFD, 7C60, 7OF9, 7OFE, 3WN7, 7OFB, 6ZF3, 5FNS, 7P5F, 6ZF5, 8Q1R, 3WDZ, 6ZF7, 7P5N, 7C5E, 6ZF0, 7P5P, 6ZEX, 6ZF8, 7P5K, 3ADE, 2Z32

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60795 Nfe2l2	17	phospho-Nfe2l2 [nucleoplasm] (R-MMU-9715109) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9715110) phospho-Nfe2l2 [cytosol] (R-MMU-8932290) phospho-Nfe2l2 [cytosol] (R-MMU-8932311) Nfe2l2 [cytosol] (R-MMU-201566) Nfe2l2 [cytosol] (R-MMU-8932335) p-Nfe2l2 [cytosol] (R-MMU-8932371) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9760033) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9760018) Nfe2l2 [nucleoplasm] (R-MMU-9759078) Nfe2l2 [cytosol] (R-MMU-9758077) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762055) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762058) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762048) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762050) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9795736) p-S,T-Nfe2l2 [cytoplasm] (R-MMU-9818709)	0.819	25
UniProt:Q64337	5	K7 ub-SQSTM1 [cytosol] (R-MMU-9759088) phospho-p-S349 SQSTM1 [cytosol] (R-MMU-9766524) phospho-ub K420 p-S349 SQSTM1 [cytosol] (R-MMU-9766536) SQSTM1 [nucleoplasm] (R-MMU-210961) SQSTM1 [cytosol] (R-MMU-193937)	0.65	6