Reactome | Shank3 [cytosol]

Shank3 [cytosol]

Stable Identifier

R-MMU-6794277

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

SHANK3, Q4ACU6

Locations in the PathwayBrowser

Expand all

Neuronal System (Mus musculus)

- Protein-protein interactions at synapses (Mus musculus)
  - Neurexins and neuroligins (Mus musculus)
    - ABP1 binds SHANK proteins (Mus musculus)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Mus musculus)
        
        SHANK1,2,3 [cytosol] (Mus musculus)
        
        Shank3 [cytosol] (Mus musculus)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Mus musculus)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Mus musculus)
        
        SHANK1,2,3 [cytosol] (Mus musculus)
        
        Shank3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q4ACU6

Gene Names

Shank3

Reference Genes

BioGPS Gene:58234 Shank3

ENSEMBL:ENSMUSG00000022623

KEGG:mmu:58234 Shank3

Monarch:58234 Shank3

NCBI Gene:58234 Shank3

UCSC:Q4ACU6 Shank3

Reference Transcript

RefSeq:NM_021423.3 Shank3

Other Identifiers

10426261

105820_at

105954_at

1419137_at

17314190

4375493

4401710

4412944

4428518

4475606

4504392

4554535

4576763

4597627

4606778

4647349

4649795

4657132

4684471

4770302

4811551

4812103

4812454

4816126

4825047

4837747

4856142

4877754

4897702

4929120

4965349

4965605

4987548

5081072

5109679

5136794

5140466

5233661

5235327

5249382

5254971

5357276

5370664

5458254

5565681

58234

A_51_P115626

A_55_P2089858

A_55_P2745254

A_55_P2745261

GE37946

GO:0000165

GO:0001664

GO:0001838

GO:0003779

GO:0005198

GO:0005515

GO:0005737

GO:0005886

GO:0007416

GO:0007611

GO:0007612

GO:0007613

GO:0007626

GO:0008092

GO:0008270

GO:0008306

GO:0010467

GO:0014009

GO:0014069

GO:0017124

GO:0021773

GO:0030154

GO:0030160

GO:0032232

GO:0034330

GO:0035176

GO:0035255

GO:0035640

GO:0035641

GO:0040011

GO:0042802

GO:0042995

GO:0043005

GO:0043197

GO:0043226

GO:0044309

GO:0044877

GO:0045202

GO:0045211

GO:0045794

GO:0048167

GO:0048170

GO:0048854

GO:0050804

GO:0050808

GO:0050877

GO:0050885

GO:0051835

GO:0051968

GO:0060076

GO:0060090

GO:0060170

GO:0060291

GO:0060292

GO:0060997

GO:0060999

GO:0061001

GO:0061351

GO:0071625

GO:0097107

GO:0097110

GO:0097113

GO:0097114

GO:0097117

GO:0097396

GO:0098919

GO:0098978

GO:0099092

GO:0099175

GO:0099562

GO:0120025

GO:1900271

GO:1900273

GO:1900451

GO:1900452

GO:1904717

GO:2000463

GO:2000821

GO:2000822

ILMN_1215372

ILMN_3163115

mMC018524

Participates

as a member of

Inferred From

SHANK3 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSP00000104932, ENSMUST00000109309, ENSMUSP00000155608, ENSMUST00000230807

PRO

Q4ACU6

GlyGen

Q4ACU6

MGI

1930016

PDB

6KYK, 3O5N, 6KYH, 5IZU

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8BKX1	1	Baiap2 [cytosol] (R-MMU-442574)	0.708	6
UniProt:Q62108 Dlg4	3	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [endocytic vesicle membrane] (R-MMU-416847) Dlg4 [cytosol] (R-MMU-6794267)	0.643	4
UniProt:P63101 Ywhaz	3	14-3-3zeta [cytosol] (R-MMU-206177) Ywhaz [nucleoplasm] (R-MMU-450469) Ywhaz [cytosol] (R-MMU-206099)	0.643	3
UniProt:O88343	1	Slc4a4 [plasma membrane] (R-MMU-425545)	0.527	3
UniProt:P48453 Ppp3cb	3	Ppp3cb [cytosol] (R-MMU-2025962) PPP3CB [nucleoplasm] (R-MMU-2685624) PPP3CB [cytosol] (R-MMU-2025869)	0.527	2
UniProt:A2CG49	2	phospho-p-KALRN [cytosol] (R-MMU-5692652) KALRN [cytosol] (R-MMU-3006505)	0.527	2
UniProt:Q9WV60 Gsk3b	3	GSK3beta [cytosol] (R-MMU-206095) Gsk3b [nucleoplasm] (R-MMU-182565) GSK3B [cytosol] (R-MMU-2997551)	0.527	2
UniProt:Q02053	2	UBA1 [nucleoplasm] (R-MMU-8852116) UBA1 [cytosol] (R-MMU-947698)	0.527	2
UniProt:P16546 Sptan1	6	SPTAN1 [tertiary granule lumen] (R-MMU-6800874) SPTAN1 [extracellular region] (R-MMU-6806322) SPTAN1 [specific granule lumen] (R-MMU-6799533) SPTAN1(1186-2472) [cytosol] (R-MMU-202964) SPTAN1(1-1185) [cytosol] (R-MMU-202944) Spectrin alpha chain, brain [cytosol] (R-MMU-681570)	0.527	2
UniProt:Q60932	6	PolyUb-VDAC1 [mitochondrial outer membrane] (R-MMU-6783079) VDAC1 [mitochondrial outer membrane] (R-MMU-1267988) Ub-VDAC1 [mitochondrial outer membrane] (R-MMU-9834989) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-MMU-5205624) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-MMU-9834037) p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-MMU-9834991)	0.527	3
UniProt:Q9Z1B3 Plcb1	2	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 [plasma membrane] (R-MMU-445858) Plcb1 [cytosol] (R-MMU-61693)	0.527	2