Uaca binds apoptosome

Stable Identifier
R-MMU-6804642
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Uaca binds apoptosome
Mouse Uaca (or nucling) is a regulatory molecule for stress-induced apoptosis, which interacts with the Apaf1/pro-caspase-9 complex, thereby acting as a stabilizer for the apoptosome. Uaca was shown to be able to induce apoptosis in mammalian cells and could promote the caspase cascade (Sakai T et al., 2004). Cells prepared from Uaca-knockout mice were resistant to proapoptotic stress induced by UV irradiation, LPS ot TNFalpha (Sakai T et al., 2004; Kim SM et al., 2013). Furthermore, Uaca was required for the translocation of Apaf1 to the nucleus after proapoptotic stress, suggesting that Uacs is a transporter of the Apaf1/procaspase-9 complex to the nucleus (Sakai T et al., 2004).
Literature References
PubMed ID Title Journal Year
15271982 Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis

Shishido, Y, Ishimura, K, Mak, TW, Toida, K, Kaji, R, Shimada, H, Sakai, T, Mitani, T, Fukui, K, Teng, X, Mukai-Sakai, R, Matsumoto, M, Liu, L

J. Biol. Chem. 2004
Participants
Input
Output
Orthologous Events
UACA binds apoptosome (Homo sapiens)
Authored
Shamovsky, V  (2018-11-02)
Reviewed
Matthews, L  (2018-11-05)
Created
Shamovsky, V  (2015-10-13)
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