Reactome | Ints6 [nucleoplasm]

Ints6 [nucleoplasm]

Stable Identifier

R-MMU-6807440

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

INTS6, Q6PCM2

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints6 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6PCM2

Gene Names

Ints6

Reference Genes

BioGPS Gene:18130 Ints6

ENSEMBL:ENSMUSG00000035161

KEGG:mmu:18130 Ints6

Monarch:18130 Ints6

NCBI Gene:18130 Ints6

UCSC:Q6PCM2 Ints6

Reference Transcript

Other Identifiers

10420694

114436_at

133133_at

134090_at

1423275_at

1436089_at

1443128_at

17307550

18130

4332914

4361337

4362841

4371153

4420778

4468493

4480468

4518436

4528460

4531720

4560351

4565036

4585843

4628337

4661791

4696953

4718372

4748175

4840506

4852388

4864704

4928220

4980122

5113010

5130879

5179207

5182557

5202529

5219586

5263282

5315455

5331966

5350582

5391086

5432166

5492433

5506311

99171_at

A_51_P415029

A_52_P466171

A_52_P49778

A_55_P2731316

A_55_P2732126

A_55_P2739167

GE34110

GO:0000785

GO:0005634

GO:0005654

GO:0005694

GO:0005856

GO:0006351

GO:0006366

GO:0006368

GO:0015629

GO:0016073

GO:0016180

GO:0030674

GO:0032039

GO:0034472

GO:0060090

GO:0071168

GO:0160232

GO:0160240

ILMN_1220343

ILMN_2451146

ILMN_3161409

Msa.2720.0_s_at

mMC013154

Participates

as a component of

Integrator [nucleoplasm] (Mus musculus)

Inferred From

INTS6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_032741.2, XP_011243288.1, XP_006518745.1, XP_017171398.1

ENSEMBL

ENSMUST00000223585, ENSMUST00000053959, ENSMUSP00000152954, ENSMUSG00000035161, ENSMUSP00000086788

PRO

Q6PCM2

GlyGen

Q6PCM2

MGI

1202397

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