Reactome | Ints1 [nucleoplasm]

Ints1 [nucleoplasm]

Stable Identifier

R-MMU-6807446

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

INTS1, Q6P4S8

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6P4S8

Gene Names

Ints1

Reference Genes

BioGPS Gene:68510 Ints1

ENSEMBL:ENSMUSG00000029547

KEGG:mmu:68510 Ints1

Monarch:68510 Ints1

NCBI Gene:68510 Ints1

UCSC:Q6P4S8 Ints1

Reference Transcript

RefSeq:NM_026748.3 Ints1

Other Identifiers

10535124

112824_at

1426943_at

17454450

4308262

4308626

4311475

4345235

4348197

4351567

4398764

4399947

4426766

4429787

4443255

4453348

4457734

4472005

4495527

4553928

4575102

4591169

4593034

4598458

4616951

4658107

4664972

4671818

4676274

4747037

4753471

4768035

4773416

4854635

4868281

4920275

4946341

4949819

4963967

4970260

4975815

4981404

4988469

5042331

5058069

5100533

5102269

5108677

5132904

5155211

5184892

5188018

5195844

5197325

5199044

5230710

5233306

5318332

5335935

5372861

5380074

5384627

5391337

5419404

5442390

5461884

5521414

5533047

5548370

5550852

5580118

68510

A_51_P295708

A_55_P2736759

GE1479750

GE1524596

GO:0001832

GO:0001833

GO:0003674

GO:0005634

GO:0007566

GO:0016020

GO:0016073

GO:0016180

GO:0022414

GO:0031965

GO:0032039

GO:0034474

GO:0043066

GO:0160232

GO:0160240

ILMN_1222829

ILMN_1253524

ILMN_2692403

mMC012105

Participates

as a component of

Integrator [nucleoplasm] (Mus musculus)

Inferred From

INTS1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_081024.4

ENSEMBL

ENSMUSG00000029547, ENSMUST00000200393, ENSMUSP00000143789

PRO

Q6P4S8

GlyGen

Q6P4S8

MGI

1915760

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