Reactome | Ints12 [nucleoplasm]

Ints12 [nucleoplasm]

Stable Identifier

R-MMU-6807456

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

INTS12, Q9D168

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints12 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9D168

Gene Names

Ints12

Reference Genes

BioGPS Gene:71793 Ints12

ENSEMBL:ENSMUSG00000028016

KEGG:mmu:71793 Ints12

Monarch:71793 Ints12

NCBI Gene:71793 Ints12

UCSC:Q9D168 Ints12

Reference Transcript

RefSeq:NM_027927.4 Ints12

Other Identifiers

10496159

115775_at

1428985_at

1452316_at

169555_r_at

17402746

4326417

4338895

4343726

4362504

4434136

4477266

4591723

4611775

4708999

4813149

4881136

4930476

4937349

5113683

5166836

5265092

5272510

5409204

5534349

5542984

5579592

71793

A_51_P284793

A_52_P1155474

A_52_P59562

A_66_P121165

GE38455

GO:0003674

GO:0005634

GO:0008270

GO:0016073

GO:0016180

GO:0032039

GO:0034472

GO:0046872

GO:0160232

GO:0160240

ILMN_1246261

ILMN_2522765

mMC004909

mMR029754

Participates

as a component of

Integrator [nucleoplasm] (Mus musculus)

Inferred From

INTS12 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_082203.1

ENSEMBL

ENSMUSG00000028016, ENSMUSP00000029650, ENSMUST00000029650

PRO

Q9D168

MGI

1919043

PDB

1WEV

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