Reactome | ORC4 [nucleoplasm]

ORC4 [nucleoplasm]

Stable Identifier

R-MMU-68519

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

O88708

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - Activation of ATR in response to replication stress (Mus musculus)
      - Activation of claspin (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - Loading of claspin onto DNA during replication origin firing (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Activation of the pre-replicative complex (Mus musculus)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        Cdt1 is displaced from the pre-replicative complex. (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        DNA polymerase alpha:primase binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        DNA polymerase epsilon binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - Switching of origins to a post-replicative state (Mus musculus)
        
        Orc1 removal from chromatin (Mus musculus)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Activation of the pre-replicative complex (Mus musculus)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
    - Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
    - Cdt1 is displaced from the pre-replicative complex. (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
    - DNA polymerase alpha:primase binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
    - DNA polymerase epsilon binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - Assembly of the ORC complex at the origin of replication (Mus musculus)
      - Formation of ORC(1-5) complex (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - Formation of ORC(1-6) complex (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
      - Formation of ORC(2-5) complex (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
    - CDC6 association with the ORC:origin complex (Mus musculus)
      - CDC6 association with ORC(1-6) at replication origins (Mus musculus)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        ORC(1-6):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5):origin of replication [nucleoplasm] (Mus musculus)
        
        ORC(1-5) [nucleoplasm] (Mus musculus)
        
        ORC(2-5) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
- Synthesis of DNA (Mus musculus)
  - Switching of origins to a post-replicative state (Mus musculus)
    - Orc1 removal from chromatin (Mus musculus)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        ORC:origin of replication [nucleoplasm] (Mus musculus)
        
        ORC4 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O88708

Reference Genes

BioGPS Gene:26428

ENSEMBL:ENSMUSG00000026761

ENSEMBL:ENSMUSG00000026761.13

KEGG Gene (Mus musculus):26428

Monarch:26428

NCBI Gene:26428

UCSC:O88708

Reference Transcript

Other Identifiers

104096_at

10482467

1423336_at

1423337_at

1453804_a_at

167861_at

17384994

26428

4363282

4485130

4568820

4592714

4612209

4725543

4763508

4833086

4848249

4855347

4867299

5178511

5211767

5405423

5453212

5453996

5489263

5534520

5552751

5560004

A_51_P381527

A_52_P376535

A_52_P456123

A_55_P2600362

A_55_P2600387

GE35846

GO:0000166

GO:0000228

GO:0000781

GO:0000808

GO:0000910

GO:0003677

GO:0003688

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0022414

GO:0040038

GO:0043226

GO:0051258

GO:0065003

GO:0140013

GO:0140657

ILMN_2600085

ILMN_2689513

mMC023023

mMR028320

Participates

as a component of

as an input of

Formation of ORC(2-5) complex (Mus musculus)

Inferred From

ORC4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006498127.1, NP_036088.3, XP_006498126.1, XP_006498128.1

Ensembl

ENSMUST00000028098, ENSMUSP00000028098, ENSMUSG00000026761

PRO

O88708

MGI

1347043

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