Reactome | CDC6 [nucleoplasm]

CDC6 [nucleoplasm]

Stable Identifier

R-MMU-68542

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

O89033

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - Activation of ATR in response to replication stress (Mus musculus)
      - Activation of claspin (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
      - Loading of claspin onto DNA during replication origin firing (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Activation of the pre-replicative complex (Mus musculus)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        Cdt1 is displaced from the pre-replicative complex (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        DNA polymerase alpha:primase binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        DNA polymerase epsilon binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - Switching of origins to a post-replicative state (Mus musculus)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
        
        Cdc6 protein is phosphorylated by CDK (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        Orc1 removal from chromatin (Mus musculus)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Activation of the pre-replicative complex (Mus musculus)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
    - Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
    - Cdt1 is displaced from the pre-replicative complex (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
    - DNA polymerase alpha:primase binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
    - DNA polymerase epsilon binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
      - pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - CDC6 association with the ORC:origin complex (Mus musculus)
      - CDC6 association with ORC(1-6) at replication origins (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        CDC6:MCM8 [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
      - MCM8 binds CDC6 (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        CDC6:MCM8 [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
- Synthesis of DNA (Mus musculus)
  - Switching of origins to a post-replicative state (Mus musculus)
    - CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
      - Cdc6 protein is phosphorylated by CDK (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
    - Orc1 removal from chromatin (Mus musculus)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6:ORC:origin complex [nucleoplasm] (Mus musculus)
        
        CDC6 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O89033

Reference Genes

BioGPS Gene:23834

ENSEMBL:ENSMUSG00000017499

ENSEMBL:ENSMUSG00000017499.16

KEGG Gene (Mus musculus):23834

Monarch:23834

NCBI Gene:23834

UCSC:O89033

Reference Transcript

Other Identifiers

10381072

103821_at

1417019_a_at

17256225

23834

4335550

4358626

4377921

4412317

4439987

4467211

4500752

4563123

4675574

4716712

5018531

5136538

5137031

5138382

5177090

5218577

5335161

5446398

5474366

5488703

5494252

5506300

5570134

A_52_P219473

A_52_P371108

A_55_P2805736

A_66_P131979

GO:0000166

GO:0000278

GO:0000910

GO:0000922

GO:0003682

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0006260

GO:0006270

GO:0007049

GO:0007059

GO:0016787

GO:0016887

GO:0019900

GO:0023052

GO:0030071

GO:0032467

GO:0033314

GO:0043226

GO:0045171

GO:0048146

GO:0051233

GO:0051301

GO:0051984

GO:0072686

GO:0140657

ILMN_1230340

ILMN_2597255

ILMN_3155217

Msa.33141.0_s_at

mMC023569

mMR029934

mMR030264

Participates

as an input of

as a component of

Other forms of this molecule

CDC6 [cytosol]

phospho-p-CDC6 [cytosol]

phospho-p-CDC6 [nucleoplasm]

Inferred From

CDC6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001020950.1, NP_035929.1

Ensembl

ENSMUSG00000017499, ENSMUST00000092706, ENSMUSP00000090382

PRO

O89033

MGI

1345150

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